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Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates.
Yan X, Kuster D, Mohanty P, Nijssen J, Pombo-García K, Rizuan A, Franzmann TM, Sergeeva A, Passos PM, George L, Wang SH, Shenoy J, Danielson HL, Honigmann A, Ayala YM, Fawzi NL, Mittal J, Alberti S, Hyman AA. Yan X, et al. Among authors: fawzi nl. bioRxiv [Preprint]. 2024 Jan 24:2024.01.23.576837. doi: 10.1101/2024.01.23.576837. bioRxiv. 2024. PMID: 38328053 Free PMC article. Preprint.
Dual DNA/RNA-binding factor regulates dynamics of hnRNP splicing condensates.
Ray M, Zaborowsky J, Mahableshwarkar P, Vaidyanathan S, Shum J, Viswanathan R, Huang A, Wang SH, Johnson V, Wake N, Conard AM, Conicella AE, Puterbaugh R, Fawzi NL, Larschan E. Ray M, et al. Among authors: fawzi nl. bioRxiv [Preprint]. 2024 Jan 12:2024.01.11.575216. doi: 10.1101/2024.01.11.575216. bioRxiv. 2024. PMID: 38260450 Free PMC article. Preprint.
Liquid-Liquid Phase Separation of the Intrinsically Disordered Domain of the Fused in Sarcoma Protein Results in Substantial Slowing of Hydration Dynamics.
Krevert CS, Chavez D, Chatterjee S, Stelzl LS, Pütz S, Roeters SJ, Rudzinski JF, Fawzi NL, Girard M, Parekh SH, Hunger J. Krevert CS, et al. Among authors: fawzi nl. J Phys Chem Lett. 2023 Dec 14;14(49):11224-11234. doi: 10.1021/acs.jpclett.3c02790. Epub 2023 Dec 6. J Phys Chem Lett. 2023. PMID: 38056002 Free PMC article.
Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains.
Guo L, Mann JR, Mauna JC, Copley KE, Wang H, Rubien JD, Odeh HM, Lin J, Lee BL, Ganser L, Robinson E, Kim KM, Murthy AC, Paul T, Portz B, Gleixner AM, Diaz Z, Carey JL, Smirnov A, Padilla G, Lavorando E, Espy C, Shang Y, Huang EJ, Chesi A, Fawzi NL, Myong S, Donnelly CJ, Shorter J. Guo L, et al. Among authors: fawzi nl. bioRxiv [Preprint]. 2023 Sep 4:2023.09.04.555754. doi: 10.1101/2023.09.04.555754. bioRxiv. 2023. PMID: 37732211 Free PMC article. Preprint.
94 results