Fauq A - Search Results

1

Substrate-targeting gamma-secretase modulators.

Kukar TL, Ladd TB, Bann MA, Fraering PC, Narlawar R, Maharvi GM, Healy B, Chapman R, Welzel AT, Price RW, Moore B, Rangachari V, Cusack B, Eriksen J, Jansen-West K, Verbeeck C, Yager D, Eckman C, Ye W, Sagi S, Cottrell BA, Torpey J, Rosenberry TL, Fauq A, Wolfe MS, Schmidt B, Walsh DM, Koo EH, Golde TE. Kukar TL, et al. Among authors: fauq a. Nature. 2008 Jun 12;453(7197):925-9. doi: 10.1038/nature07055. Nature. 2008. PMID: 18548070 Free PMC article.

2

Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production.

Kukar T, Murphy MP, Eriksen JL, Sagi SA, Weggen S, Smith TE, Ladd T, Khan MA, Kache R, Beard J, Dodson M, Merit S, Ozols VV, Anastasiadis PZ, Das P, Fauq A, Koo EH, Golde TE. Kukar T, et al. Among authors: fauq a. Nat Med. 2005 May;11(5):545-50. doi: 10.1038/nm1235. Epub 2005 Apr 17. Nat Med. 2005. PMID: 15834426

3

Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage.

Murphy MP, Uljon SN, Fraser PE, Fauq A, Lookingbill HA, Findlay KA, Smith TE, Lewis PA, McLendon DC, Wang R, Golde TE. Murphy MP, et al. Among authors: fauq a. J Biol Chem. 2000 Aug 25;275(34):26277-84. doi: 10.1074/jbc.M002812200. J Biol Chem. 2000. PMID: 10816583 Free article.

4

Cell-free assays for gamma-secretase activity.

McLendon C, Xin T, Ziani-Cherif C, Murphy MP, Findlay KA, Lewis PA, Pinnix I, Sambamurti K, Wang R, Fauq A, Golde TE. McLendon C, et al. Among authors: fauq a. FASEB J. 2000 Dec;14(15):2383-6. doi: 10.1096/fj.00-0286fje. FASEB J. 2000. PMID: 11024004

5

An empirical model of gamma-secretase activity.

Murphy MP, Wang R, Fraser PE, Fauq A, Golde TE. Murphy MP, et al. Among authors: fauq a. Ann N Y Acad Sci. 2000;920:233-40. doi: 10.1111/j.1749-6632.2000.tb06928.x. Ann N Y Acad Sci. 2000. PMID: 11193156

6

A multigram chemical synthesis of the gamma-secretase inhibitor LY411575 and its diastereoisomers.

Fauq AH, Simpson K, Maharvi GM, Golde T, Das P. Fauq AH, et al. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6392-5. doi: 10.1016/j.bmcl.2007.07.062. Epub 2007 Aug 30. Bioorg Med Chem Lett. 2007. PMID: 17897827 Free PMC article.

7

Rationally designed dehydroalanine (DeltaAla)-containing peptides inhibit amyloid-beta (Abeta) peptide aggregation.

Rangachari V, Davey ZS, Healy B, Moore BD, Sonoda LK, Cusack B, Maharvi GM, Fauq AH, Rosenberry TL. Rangachari V, et al. Biopolymers. 2009 Jun;91(6):456-65. doi: 10.1002/bip.21151. Biopolymers. 2009. PMID: 19189374

8

γ-Secretase processing and effects of γ-secretase inhibitors and modulators on long Aβ peptides in cells.

Ran Y, Cruz PE, Ladd TB, Fauq AH, Jung JI, Matthews J, Felsenstein KM, Golde TE. Ran Y, et al. Among authors: fauq ah. J Biol Chem. 2014 Feb 7;289(6):3276-87. doi: 10.1074/jbc.M113.512921. Epub 2013 Dec 18. J Biol Chem. 2014. PMID: 24352661 Free PMC article.

9

Unmasking tandem site interaction in human acetylcholinesterase. Substrate activation with a cationic acetanilide substrate.

Johnson JL, Cusack B, Davies MP, Fauq A, Rosenberry TL. Johnson JL, et al. Among authors: fauq a. Biochemistry. 2003 May 13;42(18):5438-52. doi: 10.1021/bi027065u. Biochemistry. 2003. PMID: 12731886

10

A signal peptide peptidase (SPP) reporter activity assay based on the cleavage of type II membrane protein substrates provides further evidence for an inverted orientation of the SPP active site relative to presenilin.

Nyborg AC, Jansen K, Ladd TB, Fauq A, Golde TE. Nyborg AC, et al. Among authors: fauq a. J Biol Chem. 2004 Oct 8;279(41):43148-56. doi: 10.1074/jbc.M405879200. Epub 2004 Jul 12. J Biol Chem. 2004. PMID: 15252014 Free article.

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