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OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide.
Sepulveda H, Li X, Yue X, Carlos Angel J, Arteaga-Vazquez LJ, Brown C, Brunelli M, Jansz N, Puddu F, Scotcher J, Creed P, Kennedy P, Manriquez C, Myers SA, Crawford R, Faulkner GJ, Rao A. Sepulveda H, et al. Among authors: faulkner gj. bioRxiv [Preprint]. 2024 Jan 31:2024.01.31.578097. doi: 10.1101/2024.01.31.578097. bioRxiv. 2024. PMID: 38352366 Free PMC article. Preprint.
HOPX-associated molecular programs control cardiomyocyte cell states underpinning cardiac structure and function.
Friedman CE, Cheetham SW, Negi S, Mills RJ, Ogawa M, Redd MA, Chiu HS, Shen S, Sun Y, Mizikovsky D, Bouveret R, Chen X, Voges HK, Paterson S, De Angelis JE, Andersen SB, Cao Y, Wu Y, Jafrani YMA, Yoon S, Faulkner GJ, Smith KA, Porrello E, Harvey RP, Hogan BM, Nguyen Q, Zeng J, Kikuchi K, Hudson JE, Palpant NJ. Friedman CE, et al. Among authors: faulkner gj. Dev Cell. 2024 Jan 8;59(1):91-107.e6. doi: 10.1016/j.devcel.2023.11.012. Epub 2023 Dec 12. Dev Cell. 2024. PMID: 38091997
Transient naive reprogramming corrects hiPS cells functionally and epigenetically.
Buckberry S, Liu X, Poppe D, Tan JP, Sun G, Chen J, Nguyen TV, de Mendoza A, Pflueger J, Frazer T, Vargas-Landín DB, Paynter JM, Smits N, Liu N, Ouyang JF, Rossello FJ, Chy HS, Rackham OJL, Laslett AL, Breen J, Faulkner GJ, Nefzger CM, Polo JM, Lister R. Buckberry S, et al. Among authors: faulkner gj. Nature. 2023 Aug;620(7975):863-872. doi: 10.1038/s41586-023-06424-7. Epub 2023 Aug 16. Nature. 2023. PMID: 37587336 Free PMC article.
Endogenous retroviruses can propagate TDP-43 proteinopathy.
Ferreiro ME, Faulkner GJ. Ferreiro ME, et al. Among authors: faulkner gj. Trends Neurosci. 2023 Jun;46(6):413-414. doi: 10.1016/j.tins.2023.03.011. Epub 2023 Apr 14. Trends Neurosci. 2023. PMID: 37061454
The complexity of transferring genetic information.
Strader LC, Staller MV, Willis AE, Faulkner GJ, Beggs JD, Cech TR. Strader LC, et al. Among authors: faulkner gj. Mol Cell. 2023 Feb 2;83(3):320-323. doi: 10.1016/j.molcel.2023.01.002. Mol Cell. 2023. PMID: 36736305 Free article.
Impact of retrotransposon protein L1 ORF1p expression on oncogenic pathways in hepatocellular carcinoma: the role of cytoplasmic PIN1 upregulation.
Zadran B, Sudhindar PD, Wainwright D, Bury Y, Luli S, Howarth R, McCain MV, Watson R, Huet H, Palinkas F, Berlinguer-Palmini R, Casement J, Mann DA, Oakley F, Lunec J, Reeves H, Faulkner GJ, Shukla R. Zadran B, et al. Among authors: faulkner gj. Br J Cancer. 2023 Mar;128(7):1236-1248. doi: 10.1038/s41416-023-02154-9. Epub 2023 Jan 27. Br J Cancer. 2023. PMID: 36707636 Free PMC article.
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