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Novel vaccine technologies for the 21st century.
Mascola JR, Fauci AS. Mascola JR, et al. Among authors: fauci as. Nat Rev Immunol. 2020 Feb;20(2):87-88. doi: 10.1038/s41577-019-0243-3. Nat Rev Immunol. 2020. PMID: 31712767 Free PMC article. Review.
These technologies are producing encouraging results in the development of vaccines for globally important diseases such as tuberculosis, influenza and respiratory syncytial virus. Here we highlight the most important developments in these areas over the past 18 months. .. …
These technologies are producing encouraging results in the development of vaccines for globally important diseases such as tuberculo …
A strategic approach to COVID-19 vaccine R&D.
Corey L, Mascola JR, Fauci AS, Collins FS. Corey L, et al. Among authors: fauci as. Science. 2020 May 29;368(6494):948-950. doi: 10.1126/science.abc5312. Epub 2020 May 11. Science. 2020. PMID: 32393526 No abstract available.
Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection.
Lynch RM, Boritz E, Coates EE, DeZure A, Madden P, Costner P, Enama ME, Plummer S, Holman L, Hendel CS, Gordon I, Casazza J, Conan-Cibotti M, Migueles SA, Tressler R, Bailer RT, McDermott A, Narpala S, O'Dell S, Wolf G, Lifson JD, Freemire BA, Gorelick RJ, Pandey JP, Mohan S, Chomont N, Fromentin R, Chun TW, Fauci AS, Schwartz RM, Koup RA, Douek DC, Hu Z, Capparelli E, Graham BS, Mascola JR, Ledgerwood JE; VRC 601 Study Team. Lynch RM, et al. Among authors: fauci as. Sci Transl Med. 2015 Dec 23;7(319):319ra206. doi: 10.1126/scitranslmed.aad5752. Sci Transl Med. 2015. PMID: 26702094 Clinical Trial.
Effect of HIV Antibody VRC01 on Viral Rebound after Treatment Interruption.
Bar KJ, Sneller MC, Harrison LJ, Justement JS, Overton ET, Petrone ME, Salantes DB, Seamon CA, Scheinfeld B, Kwan RW, Learn GH, Proschan MA, Kreider EF, Blazkova J, Bardsley M, Refsland EW, Messer M, Clarridge KE, Tustin NB, Madden PJ, Oden K, O'Dell SJ, Jarocki B, Shiakolas AR, Tressler RL, Doria-Rose NA, Bailer RT, Ledgerwood JE, Capparelli EV, Lynch RM, Graham BS, Moir S, Koup RA, Mascola JR, Hoxie JA, Fauci AS, Tebas P, Chun TW. Bar KJ, et al. Among authors: fauci as. N Engl J Med. 2016 Nov 24;375(21):2037-2050. doi: 10.1056/NEJMoa1608243. Epub 2016 Nov 9. N Engl J Med. 2016. PMID: 27959728 Free PMC article. Clinical Trial.
Improvement of antibody functionality by structure-guided paratope engraftment.
Liu Q, Lai YT, Zhang P, Louder MK, Pegu A, Rawi R, Asokan M, Chen X, Shen CH, Chuang GY, Yang ES, Miao H, Wang Y, Fauci AS, Kwong PD, Mascola JR, Lusso P. Liu Q, et al. Among authors: fauci as. Nat Commun. 2019 Feb 13;10(1):721. doi: 10.1038/s41467-019-08658-4. Nat Commun. 2019. PMID: 30760721 Free PMC article.
Delayed vaginal SHIV infection in VRC01 and anti-α4β7 treated rhesus macaques.
Calenda G, Frank I, Arrode-Brusés G, Pegu A, Wang K, Arthos J, Cicala C, Rogers KA, Shirreff L, Grasperge B, Blanchard JL, Maldonado S, Roberts K, Gettie A, Villinger F, Fauci AS, Mascola JR, Martinelli E. Calenda G, et al. Among authors: fauci as. PLoS Pathog. 2019 May 13;15(5):e1007776. doi: 10.1371/journal.ppat.1007776. eCollection 2019 May. PLoS Pathog. 2019. PMID: 31083697 Free PMC article.
SARS-CoV-2 Viral Variants-Tackling a Moving Target.
Mascola JR, Graham BS, Fauci AS. Mascola JR, et al. Among authors: fauci as. JAMA. 2021 Apr 6;325(13):1261-1262. doi: 10.1001/jama.2021.2088. JAMA. 2021. PMID: 33571363 No abstract available.
A multiclade env-gag VLP mRNA vaccine elicits tier-2 HIV-1-neutralizing antibodies and reduces the risk of heterologous SHIV infection in macaques.
Zhang P, Narayanan E, Liu Q, Tsybovsky Y, Boswell K, Ding S, Hu Z, Follmann D, Lin Y, Miao H, Schmeisser H, Rogers D, Falcone S, Elbashir SM, Presnyak V, Bahl K, Prabhakaran M, Chen X, Sarfo EK, Ambrozak DR, Gautam R, Martin MA, Swerczek J, Herbert R, Weiss D, Misamore J, Ciaramella G, Himansu S, Stewart-Jones G, McDermott A, Koup RA, Mascola JR, Finzi A, Carfi A, Fauci AS, Lusso P. Zhang P, et al. Among authors: fauci as. Nat Med. 2021 Dec;27(12):2234-2245. doi: 10.1038/s41591-021-01574-5. Epub 2021 Dec 9. Nat Med. 2021. PMID: 34887575
Blocking α4β7 integrin delays viral rebound in SHIVSF162P3-infected macaques treated with anti-HIV broadly neutralizing antibodies.
Frank I, Cigoli M, Arif MS, Fahlberg MD, Maldonado S, Calenda G, Pegu A, Yang ES, Rawi R, Chuang GY, Geng H, Liu C, Zhou T, Kwong PD, Arthos J, Cicala C, Grasperge BF, Blanchard JL, Gettie A, Fennessey CM, Keele BF, Vaccari M, Hope TJ, Fauci AS, Mascola JR, Martinelli E. Frank I, et al. Among authors: fauci as. Sci Transl Med. 2021 Aug 18;13(607):eabf7201. doi: 10.1126/scitranslmed.abf7201. Sci Transl Med. 2021. PMID: 34408080 Free PMC article.
1,072 results