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Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents.
Fattorusso C, Campiani G, Kukreja G, Persico M, Butini S, Romano MP, Altarelli M, Ros S, Brindisi M, Savini L, Novellino E, Nacci V, Fattorusso E, Parapini S, Basilico N, Taramelli D, Yardley V, Croft S, Borriello M, Gemma S. Fattorusso C, et al. Among authors: fattorusso e. J Med Chem. 2008 Mar 13;51(5):1333-43. doi: 10.1021/jm7012375. Epub 2008 Feb 16. J Med Chem. 2008. PMID: 18278859
Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains.
Gemma S, Kukreja G, Fattorusso C, Persico M, Romano MP, Altarelli M, Savini L, Campiani G, Fattorusso E, Basilico N, Taramelli D, Yardley V, Butini S. Gemma S, et al. Among authors: fattorusso c, fattorusso e. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5384-8. doi: 10.1016/j.bmcl.2006.07.060. Epub 2006 Aug 4. Bioorg Med Chem Lett. 2006. PMID: 16890433
Design and synthesis of potent antimalarial agents based on clotrimazole scaffold: exploring an innovative pharmacophore.
Gemma S, Campiani G, Butini S, Kukreja G, Joshi BP, Persico M, Catalanotti B, Novellino E, Fattorusso E, Nacci V, Savini L, Taramelli D, Basilico N, Morace G, Yardley V, Fattorusso C. Gemma S, et al. Among authors: fattorusso c, fattorusso e. J Med Chem. 2007 Feb 22;50(4):595-8. doi: 10.1021/jm061429p. Epub 2007 Jan 31. J Med Chem. 2007. PMID: 17263523
Clotrimazole scaffold as an innovative pharmacophore towards potent antimalarial agents: design, synthesis, and biological and structure-activity relationship studies.
Gemma S, Campiani G, Butini S, Kukreja G, Coccone SS, Joshi BP, Persico M, Nacci V, Fiorini I, Novellino E, Fattorusso E, Taglialatela-Scafati O, Savini L, Taramelli D, Basilico N, Parapini S, Morace G, Yardley V, Croft S, Coletta M, Marini S, Fattorusso C. Gemma S, et al. Among authors: fattorusso c, fattorusso e. J Med Chem. 2008 Mar 13;51(5):1278-94. doi: 10.1021/jm701247k. Epub 2008 Feb 16. J Med Chem. 2008. PMID: 18278860 Free article.
A new class of antimalarial dioxanes obtained through a simple two-step synthetic approach: rational design and structure-activity relationship studies.
Persico M, Quintavalla A, Rondinelli F, Trombini C, Lombardo M, Fattorusso C, Azzarito V, Taramelli D, Parapini S, Corbett Y, Chianese G, Fattorusso E, Taglialatela-Scafati O. Persico M, et al. Among authors: fattorusso c, fattorusso e. J Med Chem. 2011 Dec 22;54(24):8526-40. doi: 10.1021/jm201056j. Epub 2011 Nov 23. J Med Chem. 2011. PMID: 22054038
Further optimization of plakortin pharmacophore: structurally simple 4-oxymethyl-1,2-dioxanes with promising antimalarial activity.
Persico M, Parapini S, Chianese G, Fattorusso C, Lombardo M, Petrizza L, Quintavalla A, Rondinelli F, Basilico N, Taramelli D, Trombini C, Fattorusso E, Taglialatela-Scafati O. Persico M, et al. Among authors: fattorusso e. Eur J Med Chem. 2013;70:875-86. doi: 10.1016/j.ejmech.2013.10.050. Epub 2013 Oct 27. Eur J Med Chem. 2013. PMID: 24262380
166 results