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In vivo affinity maturation of the HIV-1 Env-binding domain of CD4.
Pan A, Bailey CC, Ou T, Xu J, Liu X, Hu B, Crynen G, Skamangas N, Bronkema N, Tran M, Mu H, Zhang X, Yin Y, Alpert MD, He W, Farzan M. Pan A, et al. Among authors: farzan m. Res Sq [Preprint]. 2024 Feb 9:rs.3.rs-3922904. doi: 10.21203/rs.3.rs-3922904/v1. Res Sq. 2024. PMID: 38405717 Free PMC article. Preprint.
Mutations from bat ACE2 orthologs markedly enhance ACE2-Fc neutralization of SARS-CoV-2.
Mou H, Quinlan BD, Peng H, Guo Y, Peng S, Zhang L, Davis-Gardner ME, Gardner MR, Crynen G, Voo ZX, Bailey CC, Alpert MD, Rader C, Choe H, Farzan M. Mou H, et al. Among authors: farzan m. bioRxiv [Preprint]. 2020 Jun 30:2020.06.29.178459. doi: 10.1101/2020.06.29.178459. bioRxiv. 2020. PMID: 32637954 Free PMC article. Updated. Preprint.
A more efficient CRISPR-Cas12a variant derived from Lachnospiraceae bacterium MA2020.
Tran MH, Park H, Nobles CL, Karunadharma P, Pan L, Zhong G, Wang H, He W, Ou T, Crynen G, Sheptack K, Stiskin I, Mou H, Farzan M. Tran MH, et al. Among authors: farzan m. Mol Ther Nucleic Acids. 2021 Feb 18;24:40-53. doi: 10.1016/j.omtn.2021.02.012. eCollection 2021 Jun 4. Mol Ther Nucleic Acids. 2021. PMID: 33738137 Free PMC article.
Mutations derived from horseshoe bat ACE2 orthologs enhance ACE2-Fc neutralization of SARS-CoV-2.
Mou H, Quinlan BD, Peng H, Liu G, Guo Y, Peng S, Zhang L, Davis-Gardner ME, Gardner MR, Crynen G, DeVaux LB, Voo ZX, Bailey CC, Alpert MD, Rader C, Gack MU, Choe H, Farzan M. Mou H, et al. Among authors: farzan m. PLoS Pathog. 2021 Apr 9;17(4):e1009501. doi: 10.1371/journal.ppat.1009501. eCollection 2021 Apr. PLoS Pathog. 2021. PMID: 33836016 Free PMC article.
Reprogramming of the heavy-chain CDR3 regions of a human antibody repertoire.
Ou T, He W, Quinlan BD, Guo Y, Tran MH, Karunadharma P, Park H, Davis-Gardner ME, Yin Y, Zhang X, Wang H, Zhong G, Farzan M. Ou T, et al. Among authors: farzan m. Mol Ther. 2022 Jan 5;30(1):184-197. doi: 10.1016/j.ymthe.2021.10.027. Epub 2021 Nov 2. Mol Ther. 2022. PMID: 34740791 Free PMC article.
219 results