Farrawell NE - Search Results

1

Proteome Homeostasis Dysfunction: A Unifying Principle in ALS Pathogenesis.

Yerbury JJ, Farrawell NE, McAlary L. Yerbury JJ, et al. Among authors: farrawell ne. Trends Neurosci. 2020 May;43(5):274-284. doi: 10.1016/j.tins.2020.03.002. Epub 2020 Apr 14. Trends Neurosci. 2020. PMID: 32353332 Review.

2

Ubiquitin Homeostasis Is Disrupted in TDP-43 and FUS Cell Models of ALS.

Farrawell NE, McAlary L, Lum JS, Chisholm CG, Warraich ST, Blair IP, Vine KL, Saunders DN, Yerbury JJ. Farrawell NE, et al. iScience. 2020 Oct 20;23(11):101700. doi: 10.1016/j.isci.2020.101700. eCollection 2020 Nov 20. iScience. 2020. PMID: 33196025 Free PMC article.

3

Flow cytometric measurement of the cellular propagation of TDP-43 aggregation.

Zeineddine R, Whiten DR, Farrawell NE, McAlary L, Hanspal MA, Kumita JR, Wilson MR, Yerbury JJ. Zeineddine R, et al. Among authors: farrawell ne. Prion. 2017 May 4;11(3):195-204. doi: 10.1080/19336896.2017.1314426. Epub 2017 May 9. Prion. 2017. PMID: 28486039 Free PMC article.

4

Addition of exogenous SOD1 aggregates causes TDP-43 mislocalisation and aggregation.

Zeineddine R, Farrawell NE, Lambert-Smith IA, Yerbury JJ. Zeineddine R, et al. Among authors: farrawell ne. Cell Stress Chaperones. 2017 Nov;22(6):893-902. doi: 10.1007/s12192-017-0804-y. Epub 2017 May 30. Cell Stress Chaperones. 2017. PMID: 28560609 Free PMC article.

5

SOD1^A4V aggregation alters ubiquitin homeostasis in a cell model of ALS.

Farrawell NE, Lambert-Smith I, Mitchell K, McKenna J, McAlary L, Ciryam P, Vine KL, Saunders DN, Yerbury JJ. Farrawell NE, et al. J Cell Sci. 2018 Jun 12;131(11):jcs209122. doi: 10.1242/jcs.209122. J Cell Sci. 2018. PMID: 29748379 Free PMC article.

6

Tryptophan 32-mediated SOD1 aggregation is attenuated by pyrimidine-like compounds in living cells.

Pokrishevsky E, McAlary L, Farrawell NE, Zhao B, Sher M, Yerbury JJ, Cashman NR. Pokrishevsky E, et al. Among authors: farrawell ne. Sci Rep. 2018 Oct 22;8(1):15590. doi: 10.1038/s41598-018-32835-y. Sci Rep. 2018. PMID: 30349065 Free PMC article.

7

CuATSM Protects Against the In Vitro Cytotoxicity of Wild-Type-Like Copper-Zinc Superoxide Dismutase Mutants but not Mutants That Disrupt Metal Binding.

Farrawell NE, Yerbury MR, Plotkin SS, McAlary L, Yerbury JJ. Farrawell NE, et al. ACS Chem Neurosci. 2019 Mar 20;10(3):1555-1564. doi: 10.1021/acschemneuro.8b00527. Epub 2018 Dec 7. ACS Chem Neurosci. 2019. PMID: 30462490

8

CuATSM improves motor function and extends survival but is not tolerated at a high dose in SOD1^G93A mice with a C57BL/6 background.

Lum JS, Brown ML, Farrawell NE, McAlary L, Ly D, Chisholm CG, Snow J, Vine KL, Karl T, Kreilaus F, McInnes LE, Nikseresht S, Donnelly PS, Crouch PJ, Yerbury JJ. Lum JS, et al. Among authors: farrawell ne. Sci Rep. 2021 Sep 29;11(1):19392. doi: 10.1038/s41598-021-98317-w. Sci Rep. 2021. PMID: 34588483 Free PMC article.

9

Mutant Cu/Zn Superoxide Dismutase (A4V) Turnover Is Altered in Cells Containing Inclusions.

Farrawell NE, Yerbury JJ. Farrawell NE, et al. Front Mol Neurosci. 2021 Nov 3;14:771911. doi: 10.3389/fnmol.2021.771911. eCollection 2021. Front Mol Neurosci. 2021. PMID: 34803609 Free PMC article.

10

TDP-43 is a ubiquitylation substrate of the SCF^{cyclin F} complex.

Rayner SL, Yang S, Farrawell NE, Jagaraj CJ, Cheng F, Davidson JM, Luu L, Redondo AG, Rábano A, Borrego-Hernández D, Atkin JD, Morsch M, Blair IP, Yerbury JJ, Chung R, Lee A. Rayner SL, et al. Among authors: farrawell ne. Neurobiol Dis. 2022 Jun 1;167:105673. doi: 10.1016/j.nbd.2022.105673. Epub 2022 Feb 26. Neurobiol Dis. 2022. PMID: 35231559 Free article.

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