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Time-dependent dual effect of NLRP3 inflammasome in brain ischaemia.
Palomino-Antolin A, Narros-Fernández P, Farré-Alins V, Sevilla-Montero J, Decouty-Pérez C, Lopez-Rodriguez AB, Fernández N, Monge L, Casas AI, Calzada MJ, Egea J. Palomino-Antolin A, et al. Among authors: farre alins v. Br J Pharmacol. 2022 Apr;179(7):1395-1410. doi: 10.1111/bph.15732. Epub 2022 Feb 5. Br J Pharmacol. 2022. PMID: 34773639 Free article.
Melatonin Reduces NLRP3 Inflammasome Activation by Increasing α7 nAChR-Mediated Autophagic Flux.
Farré-Alins V, Narros-Fernández P, Palomino-Antolín A, Decouty-Pérez C, Lopez-Rodriguez AB, Parada E, Muñoz-Montero A, Gómez-Rangel V, López-Muñoz F, Ramos E, González-Rodríguez Á, Gandía L, Romero A, Egea J. Farré-Alins V, et al. Antioxidants (Basel). 2020 Dec 18;9(12):1299. doi: 10.3390/antiox9121299. Antioxidants (Basel). 2020. PMID: 33353046 Free PMC article.
Serum Amyloid A1/Toll-Like Receptor-4 Axis, an Important Link between Inflammation and Outcome of TBI Patients.
Farré-Alins V, Palomino-Antolín A, Narros-Fernández P, Lopez-Rodriguez AB, Decouty-Perez C, Muñoz-Montero A, Zamorano-Fernández J, Mansilla-Fernández B, Giner-García J, García-Feijoo P, Sáez-Alegre M, Palpán-Flores AJ, Roda-Frade JM, Carabias CS, Rosa JM, Civantos-Martín B, Yus-Teruel S, Gandía L, Lagares A, Hernández-García BJ, Egea J. Farré-Alins V, et al. Biomedicines. 2021 May 25;9(6):599. doi: 10.3390/biomedicines9060599. Biomedicines. 2021. PMID: 34070533 Free PMC article.
Early toll-like receptor 4 blockade reduces ROS and inflammation triggered by microglial pro-inflammatory phenotype in rodent and human brain ischaemia models.
Parada E, Casas AI, Palomino-Antolin A, Gómez-Rangel V, Rubio-Navarro A, Farré-Alins V, Narros-Fernandez P, Guerrero-Hue M, Moreno JA, Rosa JM, Roda JM, Hernández-García BJ, Egea J. Parada E, et al. Br J Pharmacol. 2019 Aug;176(15):2764-2779. doi: 10.1111/bph.14703. Epub 2019 Jun 17. Br J Pharmacol. 2019. PMID: 31074003 Free PMC article.
TLR4 pathway impairs synaptic number and cerebrovascular functions through astrocyte activation following traumatic brain injury.
Rosa JM, Farré-Alins V, Ortega MC, Navarrete M, Lopez-Rodriguez AB, Palomino-Antolín A, Fernández-López E, Vila-Del Sol V, Decouty C, Narros-Fernández P, Clemente D, Egea J. Rosa JM, et al. Among authors: farre alins v. Br J Pharmacol. 2021 Sep;178(17):3395-3413. doi: 10.1111/bph.15488. Epub 2021 Jun 1. Br J Pharmacol. 2021. PMID: 33830504 Free PMC article.
Synthesis and Pharmacological Evaluation of New N-Sulfonylureas as NLRP3 Inflammasome Inhibitors: Identification of a Hit Compound to Treat Gout.
Narros-Fernández P, Chioua M, Petcu SA, Diez-Iriepa D, Cerrada-Gálvez L, Decouty-Pérez C, Palomino-Antolín A, Ramos E, Farré-Alins V, López-Rodríguez AB, Romero A, Marco-Contelles J, Egea J. Narros-Fernández P, et al. Among authors: farre alins v. J Med Chem. 2022 Apr 28;65(8):6250-6260. doi: 10.1021/acs.jmedchem.2c00149. Epub 2022 Apr 11. J Med Chem. 2022. PMID: 35403430
Targeting Nrf2 in Protection Against Renal Disease.
Guerrero-Hue M, Farre-Alins V, Palomino-Antolin A, Parada E, Rubio-Navarro A, Egido J, Egea J, Moreno JA. Guerrero-Hue M, et al. Curr Med Chem. 2017;24(33):3583-3605. doi: 10.2174/0929867324666170511120814. Curr Med Chem. 2017. PMID: 28494744 Review.
Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3 R Antagonism for Neurodegenerative Diseases.
Bautista-Aguilera ÓM, Hagenow S, Palomino-Antolin A, Farré-Alins V, Ismaili L, Joffrin PL, Jimeno ML, Soukup O, Janočková J, Kalinowsky L, Proschak E, Iriepa I, Moraleda I, Schwed JS, Romero Martínez A, López-Muñoz F, Chioua M, Egea J, Ramsay RR, Marco-Contelles J, Stark H. Bautista-Aguilera ÓM, et al. Angew Chem Int Ed Engl. 2017 Oct 2;56(41):12765-12769. doi: 10.1002/anie.201706072. Epub 2017 Sep 1. Angew Chem Int Ed Engl. 2017. PMID: 28861918
16 results