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Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors.
Brem J, Panduwawala T, Hansen JU, Hewitt J, Liepins E, Donets P, Espina L, Farley AJM, Shubin K, Campillos GG, Kiuru P, Shishodia S, Krahn D, Leśniak RK, Schmidt Adrian J, Calvopiña K, Turrientes MC, Kavanagh ME, Lubriks D, Hinchliffe P, Langley GW, Aboklaish AF, Eneroth A, Backlund M, Baran AG, Nielsen EI, Speake M, Kuka J, Robinson J, Grinberga S, Robinson L, McDonough MA, Rydzik AM, Leissing TM, Jimenez-Castellanos JC, Avison MB, Da Silva Pinto S, Pannifer AD, Martjuga M, Widlake E, Priede M, Hopkins Navratilova I, Gniadkowski M, Belfrage AK, Brandt P, Yli-Kauhaluoma J, Bacque E, Page MGP, Björkling F, Tyrrell JM, Spencer J, Lang PA, Baranczewski P, Cantón R, McElroy SP, Jones PS, Baquero F, Suna E, Morrison A, Walsh TR, Schofield CJ. Brem J, et al. Among authors: farley ajm. Nat Chem. 2022 Jan;14(1):15-24. doi: 10.1038/s41557-021-00831-x. Epub 2021 Dec 13. Nat Chem. 2022. PMID: 34903857
Catalytic enantioselective nucleophilic desymmetrization of phosphonate esters.
Formica M, Rogova T, Shi H, Sahara N, Ferko B, Farley AJM, Christensen KE, Duarte F, Yamazaki K, Dixon DJ. Formica M, et al. Among authors: farley ajm. Nat Chem. 2023 May;15(5):714-721. doi: 10.1038/s41557-023-01165-6. Epub 2023 May 1. Nat Chem. 2023. PMID: 37127757 Free PMC article.
C-H Cyanation of 6-Ring N-Containing Heteroaromatics.
Elbert BL, Farley AJM, Gorman TW, Johnson TC, Genicot C, Lallemand B, Pasau P, Flasz J, Castro JL, MacCoss M, Paton RS, Schofield CJ, Smith MD, Willis MC, Dixon DJ. Elbert BL, et al. Among authors: farley ajm. Chemistry. 2017 Oct 20;23(59):14733-14737. doi: 10.1002/chem.201703931. Epub 2017 Sep 22. Chemistry. 2017. PMID: 28833674 Free PMC article.
Direct sulfonylation of anilines mediated by visible light.
Johnson TC, Elbert BL, Farley AJM, Gorman TW, Genicot C, Lallemand B, Pasau P, Flasz J, Castro JL, MacCoss M, Dixon DJ, Paton RS, Schofield CJ, Smith MD, Willis MC. Johnson TC, et al. Among authors: farley ajm. Chem Sci. 2017 Nov 16;9(3):629-633. doi: 10.1039/c7sc03891g. eCollection 2018 Jan 21. Chem Sci. 2017. PMID: 29629128 Free PMC article.
Synthesis and structure-activity relationship of berkeleylactone A-derived antibiotics.
Malatinský T, Valachová D, Pinčeková L, Scherhaufer D, Olejníková P, Májeková M, Vargová J, Gaálová-Radochová B, Bujdáková H, Nováčiková J, Farley AJM, Berkeš D, Jakubec P, Kolarovič A, Caletková O. Malatinský T, et al. Among authors: farley ajm. Org Biomol Chem. 2022 Oct 12;20(39):7821-7832. doi: 10.1039/d2ob01452a. Org Biomol Chem. 2022. PMID: 36169622
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