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Fetal and maternal NLRP3 signaling is required for preterm labor and birth.
Motomura K, Romero R, Galaz J, Tao L, Garcia-Flores V, Xu Y, Done B, Arenas-Hernandez M, Miller D, Gutierrez-Contreras P, Farias-Jofre M, Aras S, Grossman LI, Tarca AL, Gomez-Lopez N. Motomura K, et al. Among authors: farias jofre m. JCI Insight. 2022 Aug 22;7(16):e158238. doi: 10.1172/jci.insight.158238. JCI Insight. 2022. PMID: 35993366 Free PMC article.
Distinct Cellular Immune Responses to SARS-CoV-2 in Pregnant Women.
Gomez-Lopez N, Romero R, Tao L, Gershater M, Leng Y, Zou C, Farias-Jofre M, Galaz J, Miller D, Tarca AL, Arenas-Hernandez M, Bhatti G, Garcia-Flores V, Liu Z, Para R, Kanninen T, Hadaya O, Paredes C, Xu Y. Gomez-Lopez N, et al. J Immunol. 2022 Apr 15;208(8):1857-1872. doi: 10.4049/jimmunol.2101123. Epub 2022 Apr 4. J Immunol. 2022. PMID: 35379748 Free PMC article.
Clarithromycin prevents preterm birth and neonatal mortality by dampening alarmin-induced maternal-fetal inflammation in mice.
Galaz J, Romero R, Arenas-Hernandez M, Farias-Jofre M, Motomura K, Liu Z, Kawahara N, Demery-Poulos C, Liu TN, Padron J, Panaitescu B, Gomez-Lopez N. Galaz J, et al. Among authors: farias jofre m. BMC Pregnancy Childbirth. 2022 Jun 20;22(1):503. doi: 10.1186/s12884-022-04764-2. BMC Pregnancy Childbirth. 2022. PMID: 35725425 Free PMC article.
Pregnancy imparts distinct systemic adaptive immune function.
Demery-Poulos C, Romero R, Xu Y, Arenas-Hernandez M, Miller D, Tao L, Galaz J, Farias-Jofre M, Bhatti G, Garcia-Flores V, Seyerle M, Tarca AL, Gomez-Lopez N. Demery-Poulos C, et al. Among authors: farias jofre m. Am J Reprod Immunol. 2022 Nov;88(5):e13606. doi: 10.1111/aji.13606. Epub 2022 Sep 6. Am J Reprod Immunol. 2022. PMID: 35989229 Free PMC article.
A key role for NLRP3 signaling in preterm labor and birth driven by the alarmin S100B.
Galaz J, Motomura K, Romero R, Liu Z, Garcia-Flores V, Tao L, Xu Y, Done B, Arenas-Hernandez M, Kanninen T, Farias-Jofre M, Miller D, Tarca AL, Gomez-Lopez N. Galaz J, et al. Among authors: farias jofre m. Transl Res. 2023 Sep;259:46-61. doi: 10.1016/j.trsl.2023.04.004. Epub 2023 Apr 28. Transl Res. 2023. PMID: 37121539
Blockade of IL-6R prevents preterm birth and adverse neonatal outcomes.
Farias-Jofre M, Romero R, Galaz J, Xu Y, Miller D, Garcia-Flores V, Arenas-Hernandez M, Winters AD, Berkowitz BA, Podolsky RH, Shen Y, Kanninen T, Panaitescu B, Glazier CR, Pique-Regi R, Theis KR, Gomez-Lopez N. Farias-Jofre M, et al. EBioMedicine. 2023 Dec;98:104865. doi: 10.1016/j.ebiom.2023.104865. Epub 2023 Nov 7. EBioMedicine. 2023. PMID: 37944273 Free PMC article.
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