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1-Aryl-1H- and 2-aryl-2H-1,2,3-triazole derivatives blockade P2X7 receptor in vitro and inflammatory response in vivo.
Gonzaga DTG, Ferreira LBG, Moreira Maramaldo Costa TE, von Ranke NL, Anastácio Furtado Pacheco P, Sposito Simões AP, Arruda JC, Dantas LP, de Freitas HR, de Melo Reis RA, Penido C, Bello ML, Castro HC, Rodrigues CR, Ferreira VF, Faria RX, da Silva FC. Gonzaga DTG, et al. Among authors: faria rx. Eur J Med Chem. 2017 Oct 20;139:698-717. doi: 10.1016/j.ejmech.2017.08.034. Epub 2017 Aug 16. Eur J Med Chem. 2017. PMID: 28858765
1,4-Naphthoquinones potently inhibiting P2X7 receptor activity.
Faria RX, Oliveira FH, Salles JP, Oliveira AS, von Ranke NL, Bello ML, Rodrigues CR, Castro HC, Louvis AR, Martins DL, Ferreira VF. Faria RX, et al. Eur J Med Chem. 2018 Jan 1;143:1361-1372. doi: 10.1016/j.ejmech.2017.10.033. Epub 2017 Oct 23. Eur J Med Chem. 2018. PMID: 29133043
8-Hydroxy-2-(1H-1,2,3-triazol-1-yl)-1,4-naphtoquinone derivatives inhibited P2X7 Receptor-Induced dye uptake into murine Macrophages.
Pacheco PAF, Galvão RMS, Faria AFM, Von Ranke NL, Rangel MS, Ribeiro TM, Bello ML, Rodrigues CR, Ferreira VF, da Rocha DR, Faria RX. Pacheco PAF, et al. Among authors: faria rx, faria afm. Bioorg Med Chem. 2019 Apr 15;27(8):1449-1455. doi: 10.1016/j.bmc.2018.11.036. Epub 2018 Nov 27. Bioorg Med Chem. 2019. PMID: 30528164
69 results