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DNA methylation of the promoter region at the CREB1 binding site is a mechanism for the epigenetic regulation of brain-specific PKMζ.
Pramio DT, Vieceli FM, Varella-Branco E, Goes CP, Kobayashi GS, da Silva Pelegrina DV, de Moraes BC, El Allam A, De Kumar B, Jara G, Farfel JM, Bennett DA, Kundu S, Viapiano MS, Reis EM, de Oliveira PSL, Dos Santos E Passos-Bueno MR, Rothlin CV, Ghosh S, Schechtman D. Pramio DT, et al. Among authors: farfel jm. Biochim Biophys Acta Gene Regul Mech. 2023 Mar;1866(1):194909. doi: 10.1016/j.bbagrm.2023.194909. Epub 2023 Jan 20. Biochim Biophys Acta Gene Regul Mech. 2023. PMID: 36682583 Free PMC article.
Brain autopsies of critically ill COVID-19 patients demonstrate heterogeneous profile of acute vascular injury, inflammation and age-linked chronic brain diseases.
Agrawal S, Farfel JM, Arfanakis K, Al-Harthi L, Shull T, Teppen TL, Evia AM, Patel MB, Ely EW, Leurgans SE, Bennett DA, Mehta R, Schneider JA. Agrawal S, et al. Among authors: farfel jm. Acta Neuropathol Commun. 2022 Dec 17;10(1):186. doi: 10.1186/s40478-022-01493-7. Acta Neuropathol Commun. 2022. PMID: 36528671 Free PMC article.
Genetic associations with dementia-related proteinopathy: Application of item response theory.
Katsumata Y, Fardo DW, Shade LMP, Wu X, Karanth SD, Hohman TJ, Schneider JA, Bennett DA, Farfel JM, Gauthreaux K, Mock C, Kukull WA, Abner EL, Nelson PT; Alzheimer's Disease Neuroimaging Initiative; National Alzheimer's Coordinating Center. Katsumata Y, et al. Among authors: farfel jm. Alzheimers Dement. 2024 Apr;20(4):2906-2921. doi: 10.1002/alz.13741. Epub 2024 Mar 9. Alzheimers Dement. 2024. PMID: 38460116 Free PMC article.
Multiple gene variants linked to Alzheimer's-type clinical dementia via GWAS are also associated with non-Alzheimer's neuropathologic entities.
Katsumata Y, Shade LM, Hohman TJ, Schneider JA, Bennett DA, Farfel JM; Alzheimer’s Disease Genetics Consortium; Kukull WA, Fardo DW, Nelson PT. Katsumata Y, et al. Among authors: farfel jm. Neurobiol Dis. 2022 Nov;174:105880. doi: 10.1016/j.nbd.2022.105880. Epub 2022 Sep 30. Neurobiol Dis. 2022. PMID: 36191742 Free PMC article.
65 results