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SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target.
Xia B, Shen X, He Y, Pan X, Liu FL, Wang Y, Yang F, Fang S, Wu Y, Duan Z, Zuo X, Xie Z, Jiang X, Xu L, Chi H, Li S, Meng Q, Zhou H, Zhou Y, Cheng X, Xin X, Jin L, Zhang HL, Yu DD, Li MH, Feng XL, Chen J, Jiang H, Xiao G, Zheng YT, Zhang LK, Shen J, Li J, Gao Z. Xia B, et al. Among authors: fang s. Cell Res. 2021 Aug;31(8):847-860. doi: 10.1038/s41422-021-00519-4. Epub 2021 Jun 10. Cell Res. 2021. PMID: 34112954 Free PMC article.
Discovery of SARS-CoV-2-E channel inhibitors as antiviral candidates.
Wang Y, Fang S, Wu Y, Cheng X, Zhang LK, Shen XR, Li SQ, Xu JR, Shang WJ, Gao ZB, Xia BQ. Wang Y, et al. Among authors: fang s. Acta Pharmacol Sin. 2022 Apr;43(4):781-787. doi: 10.1038/s41401-021-00732-2. Epub 2021 Jul 22. Acta Pharmacol Sin. 2022. PMID: 34294887 Free PMC article.
MLKL forms cation channels.
Xia B, Fang S, Chen X, Hu H, Chen P, Wang H, Gao Z. Xia B, et al. Among authors: fang s. Cell Res. 2016 May;26(5):517-28. doi: 10.1038/cr.2016.26. Epub 2016 Apr 1. Cell Res. 2016. PMID: 27033670 Free PMC article.
Sanguinarine is an agonist of TRPA1 channel.
Chi H, Zhang X, Chen X, Fang S, Ding Q, Gao Z. Chi H, et al. Among authors: fang s. Biochem Biophys Res Commun. 2021 Jan 1;534:226-232. doi: 10.1016/j.bbrc.2020.11.107. Epub 2020 Dec 1. Biochem Biophys Res Commun. 2021. PMID: 33272574
TRPA1 channel mediates organophosphate-induced delayed neuropathy.
Ding Q, Fang S, Chen X, Wang Y, Li J, Tian F, Xu X, Attali B, Xie X, Gao Z. Ding Q, et al. Among authors: fang s. Cell Discov. 2017 Aug 1;3:17024. doi: 10.1038/celldisc.2017.24. eCollection 2017. Cell Discov. 2017. PMID: 28894590 Free PMC article.
CCT128930 is a novel and potent antagonist of TRPM7 channel.
Guan Z, Chen X, Fang S, Ji Y, Gao Z, Zheng Y. Guan Z, et al. Among authors: fang s. Biochem Biophys Res Commun. 2021 Jun 30;560:132-138. doi: 10.1016/j.bbrc.2021.04.119. Epub 2021 May 11. Biochem Biophys Res Commun. 2021. PMID: 33989904
5,186 results