Fancher RM - Search Results

1

Biotransformation of Daclatasvir In Vitro and in Nonclinical Species: Formation of the Main Metabolite by Pyrrolidine δ-Oxidation and Rearrangement.

Li W, Zhao W, Liu X, Huang X, Lopez OD, Leet JE, Fancher RM, Nguyen V, Goodrich J, Easter J, Hong Y, Caceres-Cortes J, Chang SY, Ma L, Belema M, Hamann LG, Gao M, Zhu M, Shu YZ, Humphreys WG, Johnson BM. Li W, et al. Among authors: fancher rm. Drug Metab Dispos. 2016 Jun;44(6):809-20. doi: 10.1124/dmd.115.068866. Epub 2016 Mar 30. Drug Metab Dispos. 2016. PMID: 27029743

2

Cynomolgus Monkey as a Clinically Relevant Model to Study Transport Involving Renal Organic Cation Transporters: In Vitro and In Vivo Evaluation.

Shen H, Liu T, Jiang H, Titsch C, Taylor K, Kandoussi H, Qiu X, Chen C, Sukrutharaj S, Kuit K, Mintier G, Krishnamurthy P, Fancher RM, Zeng J, Rodrigues AD, Marathe P, Lai Y. Shen H, et al. Among authors: fancher rm. Drug Metab Dispos. 2016 Feb;44(2):238-49. doi: 10.1124/dmd.115.066852. Epub 2015 Nov 25. Drug Metab Dispos. 2016. PMID: 26608080

3

Investigation of the "true" extraction recovery of analytes from multiple types of tissues and its impact on tissue bioanalysis using two model compounds.

Yuan L, Ma L, Dillon L, Fancher RM, Sun H, Zhu M, Lehman-McKeeman L, Aubry AF, Ji QC. Yuan L, et al. Among authors: fancher rm. Anal Chim Acta. 2016 Nov 16;945:57-66. doi: 10.1016/j.aca.2016.09.039. Epub 2016 Oct 5. Anal Chim Acta. 2016. PMID: 27968716

4

Absorption and Disposition of Coproporphyrin I (CPI) in Cynomolgus Monkeys and Mice: Pharmacokinetic Evidence to Support the Use of CPI to Inform the Potential for Organic Anion-Transporting Polypeptide Inhibition.

Gu X, Wang L, Gan J, Fancher RM, Tian Y, Hong Y, Lai Y, Sinz M, Shen H. Gu X, et al. Among authors: fancher rm. Drug Metab Dispos. 2020 Aug;48(8):724-734. doi: 10.1124/dmd.120.090670. Epub 2020 Jun 1. Drug Metab Dispos. 2020. PMID: 32482623

5

Metabolomic Profiling and Drug Interaction Characterization Reveal Riboflavin As a Breast Cancer Resistance Protein-Specific Endogenous Biomarker That Demonstrates Prediction of Transporter Activity In Vivo.

Zhang Y, Shipkova PA, Warrack BM, Nelson DM, Wang L, Huo R, Chen J, Panfen E, Chen XQ, Fancher RM, Ruan Q, Christopher LJ, Xue Y, Sinz M, Shen H. Zhang Y, et al. Among authors: fancher rm. Drug Metab Dispos. 2023 Jul;51(7):851-861. doi: 10.1124/dmd.123.001284. Epub 2023 Apr 13. Drug Metab Dispos. 2023. PMID: 37055191

6

Evaluation of rosuvastatin as an organic anion transporting polypeptide (OATP) probe substrate: in vitro transport and in vivo disposition in cynomolgus monkeys.

Shen H, Su H, Liu T, Yao M, Mintier G, Li L, Fancher RM, Iyer R, Marathe P, Lai Y, Rodrigues AD. Shen H, et al. Among authors: fancher rm. J Pharmacol Exp Ther. 2015 May;353(2):380-91. doi: 10.1124/jpet.114.221804. Epub 2015 Mar 4. J Pharmacol Exp Ther. 2015. PMID: 25740896

7

A convenient strategy to overcome interference in LC-MS/MS analysis: Application in a microdose absolute bioavailability study.

Yuan L, Huang C, Liu-Kreyche P, Voronin K, Fancher RM, Allentoff A, Zheng N, Iyer R, Zhu L, Pillutla R, Ji QC. Yuan L, et al. Among authors: fancher rm. J Pharm Biomed Anal. 2019 Feb 20;165:198-206. doi: 10.1016/j.jpba.2018.12.014. Epub 2018 Dec 10. J Pharm Biomed Anal. 2019. PMID: 30553110

8

Absence of OATP1B (Organic Anion-Transporting Polypeptide) Induction by Rifampin in Cynomolgus Monkeys: Determination Using the Endogenous OATP1B Marker Coproporphyrin and Tissue Gene Expression.

Zhang Y, Chen C, Chen SJ, Chen XQ, Shuster DJ, Puszczalo PD, Fancher RM, Yang Z, Sinz M, Shen H. Zhang Y, et al. Among authors: fancher rm. J Pharmacol Exp Ther. 2020 Oct;375(1):139-151. doi: 10.1124/jpet.120.000139. Epub 2020 Jul 27. J Pharmacol Exp Ther. 2020. PMID: 32719071

9

Evaluation of Encequidar as An Intestinal P-gp and BCRP Specific Inhibitor to Assess the Role of Intestinal P-gp and BCRP in Drug-Drug Interactions.

Chu J, Panfen E, Wang L, Marino A, Chen XQ, Fancher RM, Landage R, Patil O, Desai SD, Shah D, Xue Y, Sinz M, Shen H. Chu J, et al. Among authors: fancher rm. Pharm Res. 2023 Nov;40(11):2567-2584. doi: 10.1007/s11095-023-03563-4. Epub 2023 Jul 31. Pharm Res. 2023. PMID: 37523014

10

Utility of gastric-retained alginate gels to modulate pharmacokinetic profiles in rats.

Foster KA, Sun H, Fancher RM, Proszynski M, Dixon G, Ford K, Cornelius G, Gudmundsson OS, Hageman MJ. Foster KA, et al. Among authors: fancher rm. J Pharm Sci. 2013 Aug;102(8):2440-9. doi: 10.1002/jps.23630. Epub 2013 Jun 6. J Pharm Sci. 2013. PMID: 23744594

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