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Page 1
Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned.
Choi R, Hulverson MA, Huang W, Vidadala RSR, Whitman GR, Barrett LK, Schaefer DA, Betzer DP, Riggs MW, Doggett JS, Hemphill A, Ortega-Mora LM, McCloskey MC, Arnold SLM, Hackman RC, Marsh KC, Lynch JJ, Freiberg GM, Leroy BE, Kempf DJ, Choy RKM, de Hostos EL, Maly DJ, Fan E, Ojo KK, Van Voorhis WC. Choi R, et al. Among authors: fan e. Int J Parasitol. 2020 May;50(5):413-422. doi: 10.1016/j.ijpara.2020.01.006. Epub 2020 Mar 26. Int J Parasitol. 2020. PMID: 32224121 Free PMC article. Review.
Buffer optimization of thermal melt assays of Plasmodium proteins for detection of small-molecule ligands.
Crowther GJ, Napuli AJ, Thomas AP, Chung DJ, Kovzun KV, Leibly DJ, Castaneda LJ, Bhandari J, Damman CJ, Hui R, Hol WG, Buckner FS, Verlinde CL, Zhang Z, Fan E, van Voorhis WC. Crowther GJ, et al. Among authors: fan e. J Biomol Screen. 2009 Jul;14(6):700-7. doi: 10.1177/1087057109335749. Epub 2009 May 21. J Biomol Screen. 2009. PMID: 19470714 Free PMC article.
Crystal structure of the aspartyl-tRNA synthetase from Entamoeba histolytica.
Merritt EA, Arakaki TL, Larson ET, Kelley A, Mueller N, Napuli AJ, Zhang L, Deditta G, Luft J, Verlinde CL, Fan E, Zucker F, Buckner FS, Van Voorhis WC, Hol WG. Merritt EA, et al. Among authors: fan e. Mol Biochem Parasitol. 2010 Feb;169(2):95-100. doi: 10.1016/j.molbiopara.2009.10.005. Epub 2009 Oct 27. Mol Biochem Parasitol. 2010. PMID: 19874856 Free PMC article.
Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs.
Merritt EA, Arakaki TL, Gillespie JR, Larson ET, Kelley A, Mueller N, Napuli AJ, Kim J, Zhang L, Verlinde CL, Fan E, Zucker F, Buckner FS, van Voorhis WC, Hol WG. Merritt EA, et al. Among authors: fan e. J Mol Biol. 2010 Mar 26;397(2):481-94. doi: 10.1016/j.jmb.2010.01.051. Epub 2010 Feb 2. J Mol Biol. 2010. PMID: 20132829 Free PMC article.
Crystal structures of three protozoan homologs of tryptophanyl-tRNA synthetase.
Merritt EA, Arakaki TL, Gillespie R, Napuli AJ, Kim JE, Buckner FS, Van Voorhis WC, Verlinde CL, Fan E, Zucker F, Hol WG. Merritt EA, et al. Among authors: fan e. Mol Biochem Parasitol. 2011 May;177(1):20-8. doi: 10.1016/j.molbiopara.2011.01.003. Epub 2011 Jan 19. Mol Biochem Parasitol. 2011. PMID: 21255615 Free PMC article.
Selective inhibitors of methionyl-tRNA synthetase have potent activity against Trypanosoma brucei Infection in Mice.
Shibata S, Gillespie JR, Kelley AM, Napuli AJ, Zhang Z, Kovzun KV, Pefley RM, Lam J, Zucker FH, Van Voorhis WC, Merritt EA, Hol WG, Verlinde CL, Fan E, Buckner FS. Shibata S, et al. Among authors: fan e. Antimicrob Agents Chemother. 2011 May;55(5):1982-9. doi: 10.1128/AAC.01796-10. Epub 2011 Jan 31. Antimicrob Agents Chemother. 2011. PMID: 21282428 Free PMC article.
Screening a fragment cocktail library using ultrafiltration.
Shibata S, Zhang Z, Korotkov KV, Delarosa J, Napuli A, Kelley AM, Mueller N, Ross J, Zucker FH, Buckner FS, Merritt EA, Verlinde CL, Van Voorhis WC, Hol WG, Fan E. Shibata S, et al. Among authors: fan e. Anal Bioanal Chem. 2011 Sep;401(5):1585-91. doi: 10.1007/s00216-011-5225-7. Epub 2011 Jul 13. Anal Bioanal Chem. 2011. PMID: 21750879 Free PMC article.
Development of Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) inhibitors with potent anti-toxoplasma activity.
Johnson SM, Murphy RC, Geiger JA, DeRocher AE, Zhang Z, Ojo KK, Larson ET, Perera BG, Dale EJ, He P, Reid MC, Fox AM, Mueller NR, Merritt EA, Fan E, Parsons M, Van Voorhis WC, Maly DJ. Johnson SM, et al. Among authors: fan e. J Med Chem. 2012 Mar 8;55(5):2416-26. doi: 10.1021/jm201713h. Epub 2012 Feb 27. J Med Chem. 2012. PMID: 22320388 Free PMC article.
Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1.
Larson ET, Ojo KK, Murphy RC, Johnson SM, Zhang Z, Kim JE, Leibly DJ, Fox AM, Reid MC, Dale EJ, Perera BG, Kim J, Hewitt SN, Hol WG, Verlinde CL, Fan E, Van Voorhis WC, Maly DJ, Merritt EA. Larson ET, et al. Among authors: fan e. J Med Chem. 2012 Mar 22;55(6):2803-10. doi: 10.1021/jm201725v. Epub 2012 Mar 13. J Med Chem. 2012. PMID: 22369268 Free PMC article.
804 results