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Low Threshold for Cutaneous Allergen Sensitization but No Spontaneous Dermatitis or Atopy in FLG-Deficient Mice.
Muhandes L, Chapsa M, Pippel M, Behrendt R, Ge Y, Dahl A, Yi B, Dalpke A, Winkler S, Hiller M, Boutin S, Beissert S, Jessberger R, Fallon PG, Roers A. Muhandes L, et al. Among authors: fallon pg. J Invest Dermatol. 2021 Nov;141(11):2611-2619.e2. doi: 10.1016/j.jid.2021.02.763. Epub 2021 Apr 22. J Invest Dermatol. 2021. PMID: 33894197 Free article.
Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects.
Saunders SP, Goh CS, Brown SJ, Palmer CN, Porter RM, Cole C, Campbell LE, Gierlinski M, Barton GJ, Schneider G, Balmain A, Prescott AR, Weidinger S, Baurecht H, Kabesch M, Gieger C, Lee YA, Tavendale R, Mukhopadhyay S, Turner SW, Madhok VB, Sullivan FM, Relton C, Burn J, Meggitt S, Smith CH, Allen MA, Barker JN, Reynolds NJ, Cordell HJ, Irvine AD, McLean WH, Sandilands A, Fallon PG. Saunders SP, et al. Among authors: fallon pg. J Allergy Clin Immunol. 2013 Nov;132(5):1121-9. doi: 10.1016/j.jaci.2013.08.046. Epub 2013 Sep 29. J Allergy Clin Immunol. 2013. PMID: 24084074 Free PMC article.
Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity.
Saunders SP, Moran T, Floudas A, Wurlod F, Kaszlikowska A, Salimi M, Quinn EM, Oliphant CJ, Núñez G, McManus R, Hams E, Irvine AD, McKenzie AN, Ogg GS, Fallon PG. Saunders SP, et al. Among authors: fallon pg. J Allergy Clin Immunol. 2016 Feb;137(2):482-91. doi: 10.1016/j.jaci.2015.06.045. Epub 2015 Aug 20. J Allergy Clin Immunol. 2016. PMID: 26299987 Free PMC article.
Neutralization of IL-17C Reduces Skin Inflammation in Mouse Models of Psoriasis and Atopic Dermatitis.
Vandeghinste N, Klattig J, Jagerschmidt C, Lavazais S, Marsais F, Haas JD, Auberval M, Lauffer F, Moran T, Ongenaert M, Van Balen M, Dupont S, Lepescheux L, Garcia T, Härtle S, Eyerich K, Fallon PG, Brys R, Steidl S. Vandeghinste N, et al. Among authors: fallon pg. J Invest Dermatol. 2018 Jul;138(7):1555-1563. doi: 10.1016/j.jid.2018.01.036. Epub 2018 Feb 21. J Invest Dermatol. 2018. PMID: 29474945 Free article.
Filaggrin Expression and Processing Deficiencies Impair Corneocyte Surface Texture and Stiffness in Mice.
Thyssen JP, Jakasa I, Riethmüller C, Schön MP, Braun A, Haftek M, Fallon PG, Wróblewski J, Jakubowski H, Eckhart L, Declercq W, Koppes S, Engebretsen KA, Bonefeld C, Irvine AD, Keita-Alassane S, Simon M, Kawasaki H, Kubo A, Amagai M, Matsui T, Kezic S. Thyssen JP, et al. Among authors: fallon pg. J Invest Dermatol. 2020 Mar;140(3):615-623.e5. doi: 10.1016/j.jid.2019.07.716. Epub 2019 Aug 31. J Invest Dermatol. 2020. PMID: 31479664 Free article.
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