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Molecular Mechanism of Antimicrobial Excipient-Induced Aggregation in Parenteral Formulations of Peptide Therapeutics.
Mol Pharm. 2022 Sep 5;19(9):3267-3278. doi: 10.1021/acs.molpharmaceut.2c00449. Epub 2022 Aug 2.
Mol Pharm. 2022.
PMID: 35917158
Diffusion Profiling of Therapeutic Proteins by Using Solution NMR Spectroscopy.
Falk BT, Liang Y, McCoy MA.
Falk BT, et al.
Chembiochem. 2019 Apr 1;20(7):896-899. doi: 10.1002/cbic.201800631. Epub 2019 Mar 4.
Chembiochem. 2019.
PMID: 30515922
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Profiling Insulin Oligomeric States by 1H NMR Spectroscopy for Formulation Development of Ultra-Rapid-Acting Insulin.
Falk BT, Liang Y, McCoy MA.
Falk BT, et al.
J Pharm Sci. 2020 Jan;109(1):922-926. doi: 10.1016/j.xphs.2019.07.025. Epub 2019 Aug 23.
J Pharm Sci. 2020.
PMID: 31449814
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Investigating protein-excipient interactions of a multivalent VHH therapeutic protein using NMR spectroscopy.
Panchal J, Falk BT, Antochshuk V, McCoy MA.
Panchal J, et al. Among authors: falk bt.
MAbs. 2022 Jan-Dec;14(1):2124902. doi: 10.1080/19420862.2022.2124902.
MAbs. 2022.
PMID: 36166705
Free PMC article.
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NMR Assessment of Therapeutic Peptides and Proteins: Correlations That Reveal Interactions and Motions.
Falk BT, Liang Y, Bailly M, Raoufi F, Kekec A, Pissarnitski D, Feng D, Yan L, Lin S, Fayadat-Dilman L, McCoy MA.
Falk BT, et al.
Chembiochem. 2020 Feb 3;21(3):315-319. doi: 10.1002/cbic.201900296. Epub 2019 Oct 24.
Chembiochem. 2020.
PMID: 31283075
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Chemical shift imprint of intersubunit communication in a symmetric homodimer.
Falk BT, Sapienza PJ, Lee AL.
Falk BT, et al.
Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9533-8. doi: 10.1073/pnas.1604748113. Epub 2016 Jul 27.
Proc Natl Acad Sci U S A. 2016.
PMID: 27466406
Free PMC article.
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Inter-Active Site Communication Mediated by the Dimer Interface β-Sheet in the Half-the-Sites Enzyme, Thymidylate Synthase.
Sapienza PJ, Popov KI, Mowrey DD, Falk BT, Dokholyan NV, Lee AL.
Sapienza PJ, et al. Among authors: falk bt.
Biochemistry. 2019 Jul 30;58(30):3302-3313. doi: 10.1021/acs.biochem.9b00486. Epub 2019 Jul 18.
Biochemistry. 2019.
PMID: 31283187
Free PMC article.
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Bacterial Thymidylate Synthase Binds Two Molecules of Substrate and Cofactor without Cooperativity.
Sapienza PJ, Falk BT, Lee AL.
Sapienza PJ, et al. Among authors: falk bt.
J Am Chem Soc. 2015 Nov 18;137(45):14260-3. doi: 10.1021/jacs.5b10128. Epub 2015 Nov 9.
J Am Chem Soc. 2015.
PMID: 26517288
Free PMC article.
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