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Halofuginone inhibits phosphorylation of SMAD-2 reducing angiogenesis and leukemia burden in an acute promyelocytic leukemia mouse model.
Assis PA, De Figueiredo-Pontes LL, Lima AS, Leão V, Cândido LA, Pintão CT, Garcia AB, Saggioro FP, Panepucci RA, Chahud F, Nagler A, Falcão RP, Rego EM. Assis PA, et al. Among authors: falcao rp. J Exp Clin Cancer Res. 2015 Jun 23;34(1):65. doi: 10.1186/s13046-015-0181-2. J Exp Clin Cancer Res. 2015. PMID: 26099922 Free PMC article.
Halofuginone has anti-proliferative effects in acute promyelocytic leukemia by modulating the transforming growth factor beta signaling pathway.
de Figueiredo-Pontes LL, Assis PA, Santana-Lemos BA, Jácomo RH, Lima AS, Garcia AB, Thomé CH, Araújo AG, Panepucci RA, Zago MA, Nagler A, Falcão RP, Rego EM. de Figueiredo-Pontes LL, et al. Among authors: falcao rp. PLoS One. 2011;6(10):e26713. doi: 10.1371/journal.pone.0026713. Epub 2011 Oct 28. PLoS One. 2011. PMID: 22053203 Free PMC article.
Methionine-induced hyperhomocysteinemia reverts fibrinolytic pathway activation in a murine model of acute promyelocytic leukemia.
Jácomo RH, Santana-Lemos BA, Lima AS, Assis PA, Lange AP, Figueiredo-Pontes LL, Oliveira LO, Bassi SC, Benício MT, Baggio MS, Garcia AB, Falcão RP, Rego EM. Jácomo RH, et al. Among authors: falcao rp. Blood. 2012 Jul 5;120(1):207-13. doi: 10.1182/blood-2011-04-347187. Epub 2012 Apr 19. Blood. 2012. PMID: 22517898 Free article.
Determination of P-glycoprotein, MDR-related protein 1, breast cancer resistance protein, and lung-resistance protein expression in leukemic stem cells of acute myeloid leukemia.
de Figueiredo-Pontes LL, Pintão MC, Oliveira LC, Dalmazzo LF, Jácomo RH, Garcia AB, Falcão RP, Rego EM. de Figueiredo-Pontes LL, et al. Among authors: falcao rp. Cytometry B Clin Cytom. 2008 May;74(3):163-8. doi: 10.1002/cyto.b.20403. Cytometry B Clin Cytom. 2008. PMID: 18200595 Free article.
134 results