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Natural Merosesquiterpenes Activate the DNA Damage Response via DNA Strand Break Formation and Trigger Apoptotic Cell Death in p53-Wild-type and Mutant Colorectal Cancer.
Jiso A, Demuth P, Bachowsky M, Haas M, Seiwert N, Heylmann D, Rasenberger B, Christmann M, Dietrich L, Brunner T, Riyanti, Schäberle TF, Plubrukarn A, Fahrer J. Jiso A, et al. Among authors: fahrer j. Cancers (Basel). 2021 Jun 30;13(13):3282. doi: 10.3390/cancers13133282. Cancers (Basel). 2021. PMID: 34209047 Free PMC article.
DNA damage response curtails detrimental replication stress and chromosomal instability induced by the dietary carcinogen PhIP.
Mimmler M, Peter S, Kraus A, Stroh S, Nikolova T, Seiwert N, Hasselwander S, Neitzel C, Haub J, Monien BH, Nicken P, Steinberg P, Shay JW, Kaina B, Fahrer J. Mimmler M, et al. Among authors: fahrer j. Nucleic Acids Res. 2016 Dec 1;44(21):10259-10276. doi: 10.1093/nar/gkw791. Epub 2016 Sep 5. Nucleic Acids Res. 2016. PMID: 27599846 Free PMC article.
PARP-1 protects against colorectal tumor induction, but promotes inflammation-driven colorectal tumor progression.
Dörsam B, Seiwert N, Foersch S, Stroh S, Nagel G, Begaliew D, Diehl E, Kraus A, McKeague M, Minneker V, Roukos V, Reißig S, Waisman A, Moehler M, Stier A, Mangerich A, Dantzer F, Kaina B, Fahrer J. Dörsam B, et al. Among authors: fahrer j. Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E4061-E4070. doi: 10.1073/pnas.1712345115. Epub 2018 Apr 9. Proc Natl Acad Sci U S A. 2018. PMID: 29632181 Free PMC article.
Formation of trans-epoxy fatty acids correlates with formation of isoprostanes and could serve as biomarker of oxidative stress.
Rund KM, Heylmann D, Seiwert N, Wecklein S, Oger C, Galano JM, Durand T, Chen R, Gueler F, Fahrer J, Bornhorst J, Schebb NH. Rund KM, et al. Among authors: fahrer j. Prostaglandins Other Lipid Mediat. 2019 Oct;144:106334. doi: 10.1016/j.prostaglandins.2019.04.004. Epub 2019 Apr 19. Prostaglandins Other Lipid Mediat. 2019. PMID: 31009766 Review.
61 results