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Discovery of 4'-[(imidazol-1-yl)methyl]biphenyl-2-sulfonamides as dual endothelin/angiotensin II receptor antagonists.
Bioorg Med Chem Lett. 2003 Mar 24;13(6):1093-6. doi: 10.1016/s0960-894x(03)00018-0.
Bioorg Med Chem Lett. 2003.
PMID: 12643919
Discovery of N-isoxazolyl biphenylsulfonamides as potent dual angiotensin II and endothelin A receptor antagonists.
Murugesan N, Tellew JE, Gu Z, Kunst BL, Fadnis L, Cornelius LA, Baska RA, Yang Y, Beyer SM, Monshizadegan H, Dickinson KE, Panchal B, Valentine MT, Chong S, Morrison RA, Carlson KE, Powell JR, Moreland S, Barrish JC, Kowala MC, Macor JE.
Murugesan N, et al. Among authors: fadnis l.
J Med Chem. 2002 Aug 29;45(18):3829-35. doi: 10.1021/jm020138n.
J Med Chem. 2002.
PMID: 12190306
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Dual angiotensin II and endothelin A receptor antagonists: synthesis of 2'-substituted N-3-isoxazolyl biphenylsulfonamides with improved potency and pharmacokinetics.
Murugesan N, Gu Z, Fadnis L, Tellew JE, Baska RA, Yang Y, Beyer SM, Monshizadegan H, Dickinson KE, Valentine MT, Humphreys WG, Lan SJ, Ewing WR, Carlson KE, Kowala MC, Zahler R, Macor JE.
Murugesan N, et al. Among authors: fadnis l.
J Med Chem. 2005 Jan 13;48(1):171-9. doi: 10.1021/jm049548x.
J Med Chem. 2005.
PMID: 15634011
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Tryptamine and homotryptamine-based sulfonamides as potent and selective inhibitors of 15-lipoxygenase.
Weinstein DS, Liu W, Gu Z, Langevine C, Ngu K, Fadnis L, Combs DW, Sitkoff D, Ahmad S, Zhuang S, Chen X, Wang FL, Loughney DA, Atwal KS, Zahler R, Macor JE, Madsen CS, Murugesan N.
Weinstein DS, et al. Among authors: fadnis l.
Bioorg Med Chem Lett. 2005 Mar 1;15(5):1435-40. doi: 10.1016/j.bmcl.2004.12.081.
Bioorg Med Chem Lett. 2005.
PMID: 15713402
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Novel dual action AT1 and ETA receptor antagonists reduce blood pressure in experimental hypertension.
Kowala MC, Murugesan N, Tellew J, Carlson K, Monshizadegan H, Ryan C, Gu Z, Kane B, Fadnis L, Baska RA, Beyer S, Arthur S, Dickinson K, Zhang D, Perrone M, Ferrer P, Giancarli M, Baumann J, Bird E, Panchal B, Yang Y, Trippodo N, Barrish J, Macor JE.
Kowala MC, et al. Among authors: fadnis l.
J Pharmacol Exp Ther. 2004 Apr;309(1):275-84. doi: 10.1124/jpet.103.055855. Epub 2004 Jan 12.
J Pharmacol Exp Ther. 2004.
PMID: 14718594
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Development of trans-2-[1H-imidazol-4-yl] cyclopropane derivatives as new high-affinity histamine H3 receptor ligands.
Tedford CE, Phillips JG, Gregory R, Pawlowski GP, Fadnis L, Khan MA, Ali SM, Handley MK, Yates SL.
Tedford CE, et al. Among authors: fadnis l.
J Pharmacol Exp Ther. 1999 May;289(2):1160-8.
J Pharmacol Exp Ther. 1999.
PMID: 10215700
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Development of a sensitive and quantitative analytical method for 1H-4-substituted imidazole histamine H3-receptor antagonists utilizing high-performance liquid chromatography and dabsyl derivatization.
Handley MK, Hirth WW, Phillips JG, Ali SM, Khan A, Fadnis L, Tedford CE.
Handley MK, et al. Among authors: fadnis l.
J Chromatogr B Biomed Sci Appl. 1998 Sep 25;716(1-2):239-49. doi: 10.1016/s0378-4347(98)00272-2.
J Chromatogr B Biomed Sci Appl. 1998.
PMID: 9824237
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Identification and pharmacological characterization of a series of new 1H-4-substituted-imidazoyl histamine H3 receptor ligands.
Yates SL, Phillips JG, Gregory R, Pawlowski GP, Fadnis L, Khan MA, Ali SM, Tedford CE.
Yates SL, et al. Among authors: fadnis l.
J Pharmacol Exp Ther. 1999 May;289(2):1151-9.
J Pharmacol Exp Ther. 1999.
PMID: 10215699
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