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Multivalent interactions essential for lentiviral integrase function.
Ballandras-Colas A, Chivukula V, Gruszka DT, Shan Z, Singh PK, Pye VE, McLean RK, Bedwell GJ, Li W, Nans A, Cook NJ, Fadel HJ, Poeschla EM, Griffiths DJ, Vargas J, Taylor IA, Lyumkis D, Yardimci H, Engelman AN, Cherepanov P. Ballandras-Colas A, et al. Among authors: fadel hj. Nat Commun. 2022 May 3;13(1):2416. doi: 10.1038/s41467-022-29928-8. Nat Commun. 2022. PMID: 35504909 Free PMC article.
Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration.
Achuthan V, Perreira JM, Sowd GA, Puray-Chavez M, McDougall WM, Paulucci-Holthauzen A, Wu X, Fadel HJ, Poeschla EM, Multani AS, Hughes SH, Sarafianos SG, Brass AL, Engelman AN. Achuthan V, et al. Among authors: fadel hj. Cell Host Microbe. 2018 Sep 12;24(3):392-404.e8. doi: 10.1016/j.chom.2018.08.002. Epub 2018 Aug 30. Cell Host Microbe. 2018. PMID: 30173955 Free PMC article.
The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase.
Slaughter A, Jurado KA, Deng N, Feng L, Kessl JJ, Shkriabai N, Larue RC, Fadel HJ, Patel PA, Jena N, Fuchs JR, Poeschla E, Levy RM, Engelman A, Kvaratskhelia M. Slaughter A, et al. Among authors: fadel hj. Retrovirology. 2014 Nov 25;11:100. doi: 10.1186/s12977-014-0100-1. Retrovirology. 2014. PMID: 25421939 Free PMC article.
31 results