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Therapeutic potential of third-generation chimeric antigen receptor T cells targeting B cell maturation antigen for treating multiple myeloma.
Rujirachaivej P, Siriboonpiputtana T, Luangwattananun P, Yuti P, Wutti-In Y, Choomee K, Sujjitjoon J, Chareonsirisuthigul T, Rerkamnuaychoke B, Junking M, Yenchitsomanus PT. Rujirachaivej P, et al. Clin Exp Med. 2024 Apr 29;24(1):90. doi: 10.1007/s10238-024-01347-7. Clin Exp Med. 2024. PMID: 38683232 Free PMC article.
However, achieving enduring clinical responses remains a challenge in CAR T cell therapy. This study developed third-generation T cells with an anti-BCMA CAR (anti-BCMA-CAR3). ...Notably, after twelve days of cultivation, anti-BCMA-CAR3 T cells nearly eradicated BCMA-posit …
However, achieving enduring clinical responses remains a challenge in CAR T cell therapy. This study developed third-generation T cel …
An increase in ER stress and unfolded protein response in iPSCs-derived neuronal cells from neuronopathic Gaucher disease patients.
Pornsukjantra T, Saikachain N, Sutjarit N, Khongkrapan A, Tubsuwan A, Bhukhai K, Tim-Aroon T, Anurathapan U, Hongeng S, Asavapanumas N. Pornsukjantra T, et al. Sci Rep. 2024 Apr 22;14(1):9177. doi: 10.1038/s41598-024-59834-6. Sci Rep. 2024. PMID: 38649404 Free PMC article.
Although neuronal death and neuroinflammation have been observed in the brains of individuals with neuronopathic Gaucher disease (nGD), the exact mechanism underlying neurodegeneration in nGD remains unclear. In this study, we used two induced pluripotent stem cells (iPSCs …
Although neuronal death and neuroinflammation have been observed in the brains of individuals with neuronopathic Gaucher disease (nGD), the …
Social processes influencing nursing students in passing the nursing licensure examination: A grounded theory approach.
Granger J, Napa W, Buadong D, Punyoo J. Granger J, et al. Nurs Open. 2024 Apr;11(4):e2148. doi: 10.1002/nop2.2148. Nurs Open. 2024. PMID: 38570917 Free PMC article.
AIM: To explore the strategies used by nursing students in passing the nursing licensure examination. DESIGN: This study uses a classic grounded theory design to explore the social processes influencing a nursing license examination. METHODS: Eight graduate students …
AIM: To explore the strategies used by nursing students in passing the nursing licensure examination. DESIGN: This study uses a class …
Process design for acidic and alcohol based deep eutectic solvent pretreatment and high pressure homogenization of palm bunches for nanocellulose production.
Sonyeam J, Chaipanya R, Suksomboon S, Khan MJ, Amatariyakul K, Wibowo A, Posoknistakul P, Charnnok B, Liu CG, Laosiripojana N, Sakdaronnarong C. Sonyeam J, et al. Sci Rep. 2024 Mar 30;14(1):7550. doi: 10.1038/s41598-024-57631-9. Sci Rep. 2024. PMID: 38555319 Free PMC article.
This research aimed to study on nanocellulose production from palm bunch using process design and cost analysis. ...
This research aimed to study on nanocellulose production from palm bunch using process design and cost analysis. ...
Occurrence and mechanisms of tigecycline resistance in carbapenem- and colistin-resistant Klebsiella pneumoniae in Thailand.
Chirabhundhu N, Luk-In S, Phuadraksa T, Wichit S, Chatsuwan T, Wannigama DL, Yainoy S. Chirabhundhu N, et al. Sci Rep. 2024 Mar 3;14(1):5215. doi: 10.1038/s41598-024-55705-2. Sci Rep. 2024. PMID: 38433246 Free PMC article.
The high incidence of tigecycline resistance observed among C-C-RKP in this study reflects an ongoing evolution of XDR bacteria against the last-resort antibiotics, which demands urgent action....
The high incidence of tigecycline resistance observed among C-C-RKP in this study reflects an ongoing evolution of XDR bacteria again …
Therapeutic Implications of Ceritinib in Cholangiocarcinoma beyond ALK Expression and Mutation.
Myint KZ, Balasubramanian B, Venkatraman S, Phimsen S, Sripramote S, Jantra J, Choeiphuk C, Mingphruedhi S, Muangkaew P, Rungsakulkij N, Tangtawee P, Suragul W, Farquharson WV, Wongprasert K, Chutipongtanate S, Sanvarinda P, Ponpuak M, Poungvarin N, Janvilisri T, Suthiphongchai T, Yacqub-Usman K, Grabowska AM, Bates DO, Tohtong R. Myint KZ, et al. Pharmaceuticals (Basel). 2024 Feb 2;17(2):197. doi: 10.3390/ph17020197. Pharmaceuticals (Basel). 2024. PMID: 38399413 Free PMC article.
Additionally, spheroid and xenograft models were employed to investigate the efficacy of ceritinib in vivo. Our study revealed that ceritinib effectively killed CCA cells at clinically relevant plasma concentrations, irrespective of ALK expression or mutation status. ...
Additionally, spheroid and xenograft models were employed to investigate the efficacy of ceritinib in vivo. Our study revealed that c …
Ov-RPA-CRISPR/Cas12a assay for the detection of Opisthorchis viverrini infection in field-collected human feces.
Phuphisut O, Poodeepiyasawat A, Yoonuan T, Watthanakulpanich D, Thawornkuno C, Reamtong O, Sato M, Adisakwattana P. Phuphisut O, et al. Parasit Vectors. 2024 Feb 21;17(1):80. doi: 10.1186/s13071-024-06134-7. Parasit Vectors. 2024. PMID: 38383404 Free PMC article.
CONCLUSIONS: The Ov-RPA-CRISPR/Cas12a assay developed in this study can successfully detect O. viverrini infection in field-collected feces. Due to the high specificity of the assay reported in this study, it can be used as an alternative approach to confirm O. vive …
CONCLUSIONS: The Ov-RPA-CRISPR/Cas12a assay developed in this study can successfully detect O. viverrini infection in field-collected …
Stimulating T cell responses against patient-derived breast cancer cells with neoantigen peptide-loaded peripheral blood mononuclear cells.
Sueangoen N, Grove H, Chuangchot N, Prasopsiri J, Rungrotmongkol T, Sanachai K, Darai N, Thongchot S, Suriyaphol P, Sa-Nguanraksa D, Thuwajit P, Yenchitsomanus PT, Thuwajit C. Sueangoen N, et al. Cancer Immunol Immunother. 2024 Feb 13;73(3):43. doi: 10.1007/s00262-024-03627-3. Cancer Immunol Immunother. 2024. PMID: 38349410 Free PMC article.
While neoantigens exhibit efficacy in activating T cells specific to cancer and instigating anti-tumor immune responses, the accuracy of neoantigen prediction remains suboptimal. In this study, we identified neoantigens from the patient-derived breast cancer cells, PC-B-14 …
While neoantigens exhibit efficacy in activating T cells specific to cancer and instigating anti-tumor immune responses, the accuracy of neo …
Agonistic Bivalent Human scFvs-Fcγ Fusion Antibodies to OX40 Ectodomain Enhance T Cell Activities against Cancer.
Mahasongkram K, Glab-Ampai K, Kaewchim K, Saenlom T, Chulanetra M, Sookrung N, Nathalang O, Chaicumpa W. Mahasongkram K, et al. Vaccines (Basel). 2023 Dec 7;11(12):1826. doi: 10.3390/vaccines11121826. Vaccines (Basel). 2023. PMID: 38140230 Free PMC article.
Furthermore, agonists of T cell costimulatory molecules (CD40, 4-1BB, OX40) play an additional anti-cancer role to that of checkpoint blocking in combined therapy and serve also as adjuvant/neoadjuvant/induction therapy to conventional cancer treatments, such as tumor resection a …
Furthermore, agonists of T cell costimulatory molecules (CD40, 4-1BB, OX40) play an additional anti-cancer role to that of checkpoint blocki …
59 results