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The benefits, limitations and opportunities of preclinical models for neonatal drug development.
Campion S, Inselman A, Hayes B, Casiraghi C, Joseph D, Facchinetti F, Salomone F, Schmitt G, Hui J, Davis-Bruno K, Van Malderen K, Morford L, De Schaepdrijver L, Wiesner L, Kourula S, Seo S, Laffan S, Urmaliya V, Chen C. Campion S, et al. Among authors: facchinetti f. Dis Model Mech. 2022 Apr 1;15(4):dmm049065. doi: 10.1242/dmm.049065. Epub 2022 Apr 25. Dis Model Mech. 2022. PMID: 35466995 Free PMC article. Review.
Melatonin as an adjunct to therapeutic hypothermia in a piglet model of neonatal encephalopathy: A translational study.
Robertson NJ, Martinello K, Lingam I, Avdic-Belltheus A, Meehan C, Alonso-Alconada D, Ragab S, Bainbridge A, Sokolska M, Tachrount M, Middleton B, Price D, Hristova M, Golay X, Soliani Raschini A, Aquino G, Pelizzi N, Facchinetti F. Robertson NJ, et al. Among authors: facchinetti f. Neurobiol Dis. 2019 Jan;121:240-251. doi: 10.1016/j.nbd.2018.10.004. Epub 2018 Oct 6. Neurobiol Dis. 2019. PMID: 30300675
Primary pulmonary arterial hypertension: Protocol to assess comprehensively in the rat the response to pharmacologic treatments.
Novelli D, Fumagalli F, Staszewsky L, Ristagno G, Olivari D, Masson S, De Giorgio D, Ceriani S, Massafra R, De Logu F, Nassini R, Milioli M, Facchinetti F, Cantoni S, Trevisani M, Letizia T, Russo I, Salio M, Latini R. Novelli D, et al. Among authors: facchinetti f. MethodsX. 2019 Dec 19;7:100771. doi: 10.1016/j.mex.2019.100771. eCollection 2020. MethodsX. 2019. PMID: 31993338 Free PMC article.
The PDE4 inhibitor tanimilast shows distinct immunomodulatory properties associated with a type 2 endotype and CD141 upregulation.
Nguyen HO, Salvi V, Tiberio L, Facchinetti F, Govoni M, Villetti G, Civelli M, Barbazza I, Gaudenzi C, Passari M, Schioppa T, Sozio F, Del Prete A, Sozzani S, Bosisio D. Nguyen HO, et al. Among authors: facchinetti f. J Transl Med. 2022 May 10;20(1):203. doi: 10.1186/s12967-022-03402-x. J Transl Med. 2022. PMID: 35538539 Free PMC article.
Monocrotaline-induced pulmonary arterial hypertension: Time-course of injury and comparative evaluation of macitentan and Y-27632, a Rho kinase inhibitor.
Novelli D, Fumagalli F, Staszewsky L, Ristagno G, Olivari D, Masson S, De Giorgio D, Ceriani S, Affatato R, De Logu F, Nassini R, Milioli M, Facchinetti F, Cantoni S, Trevisani M, Letizia T, Russo I, Salio M, Latini R. Novelli D, et al. Among authors: facchinetti f. Eur J Pharmacol. 2019 Dec 15;865:172777. doi: 10.1016/j.ejphar.2019.172777. Epub 2019 Nov 4. Eur J Pharmacol. 2019. PMID: 31697933
753 results