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Acid ceramidase improves mitochondrial function and oxidative stress in Niemann-Pick type C disease by repressing STARD1 expression and mitochondrial cholesterol accumulation.
Torres S, Solsona-Vilarrasa E, Nuñez S, Matías N, Insausti-Urkia N, Castro F, Casasempere M, Fabriás G, Casas J, Enrich C, Fernández-Checa JC, Garcia-Ruiz C. Torres S, et al. Among authors: fabrias g. Redox Biol. 2021 Sep;45:102052. doi: 10.1016/j.redox.2021.102052. Epub 2021 Jun 19. Redox Biol. 2021. PMID: 34175669 Free PMC article.
Simultaneous Inhibition of Ceramide Hydrolysis and Glycosylation Synergizes to Corrupt Mitochondrial Respiration and Signal Caspase Driven Cell Death in Drug-Resistant Acute Myeloid Leukemia.
Fisher-Wellman KH, Kassai M, Hagen JT, Neufer PD, Kester M, Loughran TP Jr, Chalfant CE, Feith DJ, Tan SF, Fox TE, Ung J, Fabrias G, Abad JL, Sharma A, Golla U, Claxton DF, Shaw JJP, Bhowmick D, Cabot MC. Fisher-Wellman KH, et al. Among authors: fabrias g. Cancers (Basel). 2023 Mar 21;15(6):1883. doi: 10.3390/cancers15061883. Cancers (Basel). 2023. PMID: 36980769 Free PMC article.
Inhibitors of sphingolipid metabolism enzymes.
Delgado A, Casas J, Llebaria A, Abad JL, Fabrias G. Delgado A, et al. Among authors: fabrias g. Biochim Biophys Acta. 2006 Dec;1758(12):1957-77. doi: 10.1016/j.bbamem.2006.08.017. Epub 2006 Sep 1. Biochim Biophys Acta. 2006. PMID: 17049336 Free article. Review.
132 results