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In vivo genome editing using novel AAV-PHP variants rescues motor function deficits and extends survival in a SOD1-ALS mouse model.
Chen YA, Kankel MW, Hana S, Lau SK, Zavodszky MI, McKissick O, Mastrangelo N, Dion J, Wang B, Ferretti D, Koske D, Lehman S, Koszka K, McLaughlin H, Liu M, Marshall E, Fabian AJ, Cullen P, Marsh G, Hamann S, Craft M, Sebalusky J, Arnold HM, Driscoll R, Sheehy A, Luo Y, Manca S, Carlile T, Sun C, Sigrist K, McCampbell A, Henderson CE, Lo SC. Chen YA, et al. Among authors: fabian aj. Gene Ther. 2023 May;30(5):443-454. doi: 10.1038/s41434-022-00375-w. Epub 2022 Dec 1. Gene Ther. 2023. PMID: 36450833 Free PMC article.
Highly efficient neuronal gene knockout in vivo by CRISPR-Cas9 via neonatal intracerebroventricular injection of AAV in mice.
Hana S, Peterson M, McLaughlin H, Marshall E, Fabian AJ, McKissick O, Koszka K, Marsh G, Craft M, Xu S, Sorets A, Torregrosa T, Sun C, Henderson CE, Lo SC. Hana S, et al. Among authors: fabian aj. Gene Ther. 2021 Nov;28(10-11):646-658. doi: 10.1038/s41434-021-00224-2. Epub 2021 Feb 8. Gene Ther. 2021. PMID: 33558692 Free PMC article.
The in vivo genetic program of murine primordial lung epithelial progenitors.
Ikonomou L, Herriges MJ, Lewandowski SL, Marsland R 3rd, Villacorta-Martin C, Caballero IS, Frank DB, Sanghrajka RM, Dame K, Kańduła MM, Hicks-Berthet J, Lawton ML, Christodoulou C, Fabian AJ, Kolaczyk E, Varelas X, Morrisey EE, Shannon JM, Mehta P, Kotton DN. Ikonomou L, et al. Among authors: fabian aj. Nat Commun. 2020 Jan 31;11(1):635. doi: 10.1038/s41467-020-14348-3. Nat Commun. 2020. PMID: 32005814 Free PMC article.
Telomere dysfunction induces metabolic and mitochondrial compromise.
Sahin E, Colla S, Liesa M, Moslehi J, Müller FL, Guo M, Cooper M, Kotton D, Fabian AJ, Walkey C, Maser RS, Tonon G, Foerster F, Xiong R, Wang YA, Shukla SA, Jaskelioff M, Martin ES, Heffernan TP, Protopopov A, Ivanova E, Mahoney JE, Kost-Alimova M, Perry SR, Bronson R, Liao R, Mulligan R, Shirihai OS, Chin L, DePinho RA. Sahin E, et al. Among authors: fabian aj. Nature. 2011 Feb 17;470(7334):359-65. doi: 10.1038/nature09787. Epub 2011 Feb 9. Nature. 2011. PMID: 21307849 Free PMC article.
Failure of bone marrow to reconstitute lung epithelium.
Kotton DN, Fabian AJ, Mulligan RC. Kotton DN, et al. Among authors: fabian aj. Am J Respir Cell Mol Biol. 2005 Oct;33(4):328-34. doi: 10.1165/rcmb.2005-0175RC. Epub 2005 Jun 16. Am J Respir Cell Mol Biol. 2005. PMID: 15961722 Free PMC article.
14 results