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Mechanism of Action of an EPAC1-Selective Competitive Partial Agonist.
Shao H, Mohamed H, Boulton S, Huang J, Wang P, Chen H, Zhou J, Luchowska-Stańska U, Jentsch NG, Armstrong AL, Magolan J, Yarwood S, Melacini G. Shao H, et al. J Med Chem. 2020 May 14;63(9):4762-4775. doi: 10.1021/acs.jmedchem.9b02151. Epub 2020 Apr 16. J Med Chem. 2020. PMID: 32297742
Identification of A Novel Class of Benzofuran Oxoacetic Acid-Derived Ligands that Selectively Activate Cellular EPAC1.
Beck EM, Parnell E, Cowley A, Porter A, Gillespie J, Robinson J, Robinson L, Pannifer AD, Hamon V, Jones P, Morrison A, McElroy S, Timmerman M, Rutjes H, Mahajan P, Wiejak J, Luchowska-Stańska U, Morgan D, Barker G, Rehmann H, Yarwood SJ. Beck EM, et al. Cells. 2019 Nov 12;8(11):1425. doi: 10.3390/cells8111425. Cells. 2019. PMID: 31726720 Free PMC article.
Selective small-molecule EPAC activators.
Luchowska-Stańska U, Morgan D, Yarwood SJ, Barker G. Luchowska-Stańska U, et al. Biochem Soc Trans. 2019 Oct 31;47(5):1415-1427. doi: 10.1042/BST20190254. Biochem Soc Trans. 2019. PMID: 31671184 Free PMC article. Review.
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