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Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease.
Milligan JC, Zeisner TU, Papageorgiou G, Joshi D, Soudy C, Ulferts R, Wu M, Lim CT, Tan KW, Weissmann F, Canal B, Fujisawa R, Deegan T, Nagaraj H, Bineva-Todd G, Basier C, Curran JF, Howell M, Beale R, Labib K, O'Reilly N, Diffley JFX. Milligan JC, et al. Biochem J. 2021 Jul 16;478(13):2499-2515. doi: 10.1042/BCJ20210197. Biochem J. 2021. PMID: 34198327 Free PMC article.
Cryo-EM structure of a licensed DNA replication origin.
Abid Ali F, Douglas ME, Locke J, Pye VE, Nans A, Diffley JFX, Costa A. Abid Ali F, et al. Nat Commun. 2017 Dec 21;8(1):2241. doi: 10.1038/s41467-017-02389-0. Nat Commun. 2017. PMID: 29269875 Free PMC article.
Cdt1 stabilizes an open MCM ring for helicase loading.
Frigola J, He J, Kinkelin K, Pye VE, Renault L, Douglas ME, Remus D, Cherepanov P, Costa A, Diffley JFX. Frigola J, et al. Nat Commun. 2017 Jun 23;8:15720. doi: 10.1038/ncomms15720. Nat Commun. 2017. PMID: 28643783 Free PMC article.