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Table representation of search results timeline featuring number of search results per year.
Year | Number of Results |
---|---|
2017 | 2 |
2018 | 1 |
2020 | 1 |
2022 | 1 |
2023 | 1 |
2024 | 0 |
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Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils.
Proc Natl Acad Sci U S A. 2023 Oct 10;120(41):e2300258120. doi: 10.1073/pnas.2300258120. Epub 2023 Oct 6.
Proc Natl Acad Sci U S A. 2023.
PMID: 37801475
Free PMC article.
Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro.
Seidler PM, Murray KA, Boyer DR, Ge P, Sawaya MR, Hu CJ, Cheng X, Abskharon R, Pan H, DeTure MA, Williams CK, Dickson DW, Vinters HV, Eisenberg DS.
Seidler PM, et al.
Nat Commun. 2022 Sep 16;13(1):5451. doi: 10.1038/s41467-022-32951-4.
Nat Commun. 2022.
PMID: 36114178
Free PMC article.
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Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease.
Abskharon R, Seidler PM, Sawaya MR, Cascio D, Yang TP, Philipp S, Williams CK, Newell KL, Ghetti B, DeTure MA, Dickson DW, Vinters HV, Felgner PL, Nakajima R, Glabe CG, Eisenberg DS.
Abskharon R, et al.
J Biol Chem. 2020 Jul 31;295(31):10662-10676. doi: 10.1074/jbc.RA120.013638. Epub 2020 Jun 3.
J Biol Chem. 2020.
PMID: 32493775
Free PMC article.
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Structure-based inhibitors of tau aggregation.
Seidler PM, Boyer DR, Rodriguez JA, Sawaya MR, Cascio D, Murray K, Gonen T, Eisenberg DS.
Seidler PM, et al.
Nat Chem. 2018 Feb;10(2):170-176. doi: 10.1038/nchem.2889. Epub 2017 Nov 20.
Nat Chem. 2018.
PMID: 29359764
Free PMC article.
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Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED.
de la Cruz MJ, Hattne J, Shi D, Seidler P, Rodriguez J, Reyes FE, Sawaya MR, Cascio D, Weiss SC, Kim SK, Hinck CS, Hinck AP, Calero G, Eisenberg D, Gonen T.
de la Cruz MJ, et al.
Nat Methods. 2017 Feb 13;14(4):399-402. doi: 10.1038/nmeth.4178.
Nat Methods. 2017.
PMID: 28192420
Free PMC article.
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