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Clinical trial perspective for adult and juvenile Huntington's disease using genetically-engineered mesenchymal stem cells.
Neural Regen Res. 2016 May;11(5):702-5. doi: 10.4103/1673-5374.182682.
Neural Regen Res. 2016.
PMID: 27335539
Free PMC article.
Review.
Engineered BDNF producing cells as a potential treatment for neurologic disease.
Deng P, Anderson JD, Yu AS, Annett G, Fink KD, Nolta JA.
Deng P, et al.
Expert Opin Biol Ther. 2016 Aug;16(8):1025-33. doi: 10.1080/14712598.2016.1183641. Epub 2016 May 21.
Expert Opin Biol Ther. 2016.
PMID: 27159050
Free PMC article.
Review.
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Allele-Specific Reduction of the Mutant Huntingtin Allele Using Transcription Activator-Like Effectors in Human Huntington's Disease Fibroblasts.
Fink KD, Deng P, Gutierrez J, Anderson JS, Torrest A, Komarla A, Kalomoiris S, Cary W, Anderson JD, Gruenloh W, Duffy A, Tempkin T, Annett G, Wheelock V, Segal DJ, Nolta JA.
Fink KD, et al.
Cell Transplant. 2016;25(4):677-86. doi: 10.3727/096368916X690863. Epub 2016 Feb 4.
Cell Transplant. 2016.
PMID: 26850319
Free PMC article.
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Human Mesenchymal Stem Cells Genetically Engineered to Overexpress Brain-derived Neurotrophic Factor Improve Outcomes in Huntington's Disease Mouse Models.
Pollock K, Dahlenburg H, Nelson H, Fink KD, Cary W, Hendrix K, Annett G, Torrest A, Deng P, Gutierrez J, Nacey C, Pepper K, Kalomoiris S, D Anderson J, McGee J, Gruenloh W, Fury B, Bauer G, Duffy A, Tempkin T, Wheelock V, Nolta JA.
Pollock K, et al.
Mol Ther. 2016 May;24(5):965-77. doi: 10.1038/mt.2016.12. Epub 2016 Jan 14.
Mol Ther. 2016.
PMID: 26765769
Free PMC article.
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