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A Novel Protective Role for Matrix Metalloproteinase-8 in the Pulmonary Vasculature.
Dieffenbach PB, Mallarino Haeger C, Rehman R, Corcoran AM, Coronata AMF, Vellarikkal SK, Chrobak I, Waxman AB, Vitali SH, Sholl LM, Padera RF, Lagares D, Polverino F, Owen CA, Fredenburgh LE. Dieffenbach PB, et al. Am J Respir Crit Care Med. 2021 Dec 15;204(12):1433-1451. doi: 10.1164/rccm.202108-1863OC. Am J Respir Crit Care Med. 2021. PMID: 34550870 Free PMC article.
NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension.
Samokhin AO, Stephens T, Wertheim BM, Wang RS, Vargas SO, Yung LM, Cao M, Brown M, Arons E, Dieffenbach PB, Fewell JG, Matar M, Bowman FP, Haley KJ, Alba GA, Marino SM, Kumar R, Rosas IO, Waxman AB, Oldham WM, Khanna D, Graham BB, Seo S, Gladyshev VN, Yu PB, Fredenburgh LE, Loscalzo J, Leopold JA, Maron BA. Samokhin AO, et al. Sci Transl Med. 2018 Jun 13;10(445):eaap7294. doi: 10.1126/scitranslmed.aap7294. Sci Transl Med. 2018. PMID: 29899023 Free PMC article.
Distal vessel stiffening is an early and pivotal mechanobiological regulator of vascular remodeling and pulmonary hypertension.
Liu F, Haeger CM, Dieffenbach PB, Sicard D, Chrobak I, Coronata AM, Suárez Velandia MM, Vitali S, Colas RA, Norris PC, Marinković A, Liu X, Ma J, Rose CD, Lee SJ, Comhair SA, Erzurum SC, McDonald JD, Serhan CN, Walsh SR, Tschumperlin DJ, Fredenburgh LE. Liu F, et al. JCI Insight. 2016 Jun 2;1(8):e86987. doi: 10.1172/jci.insight.86987. JCI Insight. 2016. PMID: 27347562 Free PMC article.