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Metabolic Injury of Hepatocytes Promotes Progression of NAFLD and AALD.
Carvalho-Gontijo R, Han C, Zhang L, Zhang V, Hosseini M, Mekeel K, Schnabl B, Loomba R, Karin M, Brenner DA, Kisseleva T. Carvalho-Gontijo R, et al. Semin Liver Dis. 2022 Aug;42(3):233-249. doi: 10.1055/s-0042-1755316. Epub 2022 Aug 24. Semin Liver Dis. 2022. PMID: 36001995 Free PMC article. Review.
Immunotherapy-based targeting of MSLN+ activated portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis.
Nishio T, Koyama Y, Liu X, Rosenthal SB, Yamamoto G, Fuji H, Baglieri J, Li N, Brenner LN, Iwaisako K, Taura K, Hagood JS, LaRusso NF, Bera TK, Pastan I, Brenner DA, Kisseleva T. Nishio T, et al. Proc Natl Acad Sci U S A. 2021 Jul 20;118(29):e2101270118. doi: 10.1073/pnas.2101270118. Proc Natl Acad Sci U S A. 2021. PMID: 34253615 Free PMC article.
Identification of Lineage-Specific Transcription Factors That Prevent Activation of Hepatic Stellate Cells and Promote Fibrosis Resolution.
Liu X, Xu J, Rosenthal S, Zhang LJ, McCubbin R, Meshgin N, Shang L, Koyama Y, Ma HY, Sharma S, Heinz S, Glass CK, Benner C, Brenner DA, Kisseleva T. Liu X, et al. Gastroenterology. 2020 May;158(6):1728-1744.e14. doi: 10.1053/j.gastro.2020.01.027. Epub 2020 Jan 23. Gastroenterology. 2020. PMID: 31982409 Free PMC article.