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ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids.
Nature. 2022 Jun;606(7916):968-975. doi: 10.1038/s41586-022-04787-x. Epub 2022 Jun 8.
Nature. 2022.
PMID: 35676490
Free PMC article.
Distinct biological activities of isomers from several families of branched fatty acid esters of hydroxy fatty acids (FAHFAs).
Aryal P, Syed I, Lee J, Patel R, Nelson AT, Siegel D, Saghatelian A, Kahn BB.
Aryal P, et al.
J Lipid Res. 2021;62:100108. doi: 10.1016/j.jlr.2021.100108. Epub 2021 Aug 18.
J Lipid Res. 2021.
PMID: 34418413
Free PMC article.
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PAHSAs enhance hepatic and systemic insulin sensitivity through direct and indirect mechanisms.
Zhou P, Santoro A, Peroni OD, Nelson AT, Saghatelian A, Siegel D, Kahn BB.
Zhou P, et al.
J Clin Invest. 2019 Oct 1;129(10):4138-4150. doi: 10.1172/JCI127092.
J Clin Invest. 2019.
PMID: 31449056
Free PMC article.
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Faster Protocol for Endogenous Fatty Acid Esters of Hydroxy Fatty Acid (FAHFA) Measurements.
Kolar MJ, Nelson AT, Chang T, Ertunc ME, Christy MP, Ohlsson L, Härröd M, Kahn BB, Siegel D, Saghatelian A.
Kolar MJ, et al.
Anal Chem. 2018 Apr 17;90(8):5358-5365. doi: 10.1021/acs.analchem.8b00503. Epub 2018 Mar 26.
Anal Chem. 2018.
PMID: 29578702
Free PMC article.
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Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis.
Syed I, Lee J, Moraes-Vieira PM, Donaldson CJ, Sontheimer A, Aryal P, Wellenstein K, Kolar MJ, Nelson AT, Siegel D, Mokrosinski J, Farooqi IS, Zhao JJ, Yore MM, Peroni OD, Saghatelian A, Kahn BB.
Syed I, et al.
Cell Metab. 2018 Feb 6;27(2):419-427.e4. doi: 10.1016/j.cmet.2018.01.001.
Cell Metab. 2018.
PMID: 29414687
Free PMC article.
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Stereochemistry of Endogenous Palmitic Acid Ester of 9-Hydroxystearic Acid and Relevance of Absolute Configuration to Regulation.
Nelson AT, Kolar MJ, Chu Q, Syed I, Kahn BB, Saghatelian A, Siegel D.
Nelson AT, et al.
J Am Chem Soc. 2017 Apr 5;139(13):4943-4947. doi: 10.1021/jacs.7b01269. Epub 2017 Mar 28.
J Am Chem Soc. 2017.
PMID: 28350171
Free PMC article.
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