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Ligand-based design and synthesis of N'-Benzylidene-3,4-dimethoxybenzohydrazide derivatives as potential antimicrobial agents; evaluation by in vitro, in vivo, and in silico approaches with SAR studies.
J Enzyme Inhib Med Chem. 2022 Dec;37(1):1098-1119. doi: 10.1080/14756366.2022.2063282.
J Enzyme Inhib Med Chem. 2022.
PMID: 35430934
Free PMC article.
1,3,4-Oxadiazole-naphthalene hybrids as potential VEGFR-2 inhibitors: design, synthesis, antiproliferative activity, apoptotic effect, and in silico studies.
Hagras M, Saleh MA, Ezz Eldin RR, Abuelkhir AA, Khidr EG, El-Husseiny AA, El-Mahdy HA, Elkaeed EB, Eissa IH.
Hagras M, et al. Among authors: ezz eldin rr.
J Enzyme Inhib Med Chem. 2022 Dec;37(1):380-396. doi: 10.1080/14756366.2021.2015342.
J Enzyme Inhib Med Chem. 2022.
PMID: 34923885
Free PMC article.
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Pharmacophore-linked pyrazolo[3,4-d]pyrimidines as EGFR-TK inhibitors: Synthesis, anticancer evaluation, pharmacokinetics, and in silico mechanistic studies.
Gaber AA, El-Morsy AM, Sherbiny FF, Bayoumi AH, El-Gamal KM, El-Adl K, Al-Karmalawy AA, Ezz Eldin RR, Saleh MA, Abulkhair HS.
Gaber AA, et al. Among authors: ezz eldin rr.
Arch Pharm (Weinheim). 2021 Aug 31:e2100258. doi: 10.1002/ardp.202100258. Online ahead of print.
Arch Pharm (Weinheim). 2021.
PMID: 34467546
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Structure based design and synthesis of 3-(7-nitro-3-oxo-3,4-dihydroquinoxalin-2-yl)propanehydrazide derivatives as novel bacterial DNA-gyrase inhibitors: In-vitro, In-vivo, In-silico and SAR studies.
Saleh MA, Elmaaty AA, El Saeed HS, Saleh MM, Salah M, Ezz Eldin RR.
Saleh MA, et al. Among authors: ezz eldin rr.
Bioorg Chem. 2022 Dec;129:106186. doi: 10.1016/j.bioorg.2022.106186. Epub 2022 Oct 5.
Bioorg Chem. 2022.
PMID: 36215786
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In vivo screening and toxicity studies of indolinone incorporated thiosemicarbazone, thiazole and piperidinosulfonyl moieties as anticonvulsant agents.
Fayed EA, Ragab A, Ezz Eldin RR, Bayoumi AH, Ammar YA.
Fayed EA, et al. Among authors: ezz eldin rr.
Bioorg Chem. 2021 Nov;116:105300. doi: 10.1016/j.bioorg.2021.105300. Epub 2021 Aug 24.
Bioorg Chem. 2021.
PMID: 34525393
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Design and Synthesis of Novel 5-((3-(Trifluoromethyl)piperidin-1-yl)sulfonyl)indoline-2,3-dione Derivatives as Promising Antiviral Agents: In Vitro, In Silico, and Structure-Activity Relationship Studies.
Ezz Eldin RR, Saleh MA, Alwarsh SA, Rushdi A, Althoqapy AA, El Saeed HS, Abo Elmaaty A.
Ezz Eldin RR, et al.
Pharmaceuticals (Basel). 2023 Sep 4;16(9):1247. doi: 10.3390/ph16091247.
Pharmaceuticals (Basel). 2023.
PMID: 37765055
Free PMC article.
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