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AT-752 targets multiple sites and activities on the Dengue virus replication enzyme NS5.
Feracci M, Eydoux C, Fattorini V, Lo Bello L, Gauffre P, Selisko B, Sutto-Ortiz P, Shannon A, Xia H, Shi PY, Noel M, Debart F, Vasseur JJ, Good S, Lin K, Moussa A, Sommadossi JP, Chazot A, Alvarez K, Guillemot JC, Decroly E, Ferron F, Canard B. Feracci M, et al. Among authors: eydoux c. Antiviral Res. 2023 Apr;212:105574. doi: 10.1016/j.antiviral.2023.105574. Epub 2023 Mar 9. Antiviral Res. 2023. PMID: 36905944
Approved drugs screening against the nsP1 capping enzyme of Venezuelan equine encephalitis virus using an immuno-based assay.
Ferreira-Ramos AS, Li C, Eydoux C, Contreras JM, Morice C, Quérat G, Gigante A, Pérez Pérez MJ, Jung ML, Canard B, Guillemot JC, Decroly E, Coutard B. Ferreira-Ramos AS, et al. Among authors: eydoux c. Antiviral Res. 2019 Mar;163:59-69. doi: 10.1016/j.antiviral.2019.01.003. Epub 2019 Jan 11. Antiviral Res. 2019. PMID: 30639438
Novel 2-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,3,4-oxadiazole and 3-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,2,4-oxadiazole derivatives as dengue virus inhibitors targeting NS5 polymerase.
Benmansour F, Eydoux C, Querat G, de Lamballerie X, Canard B, Alvarez K, Guillemot JC, Barral K. Benmansour F, et al. Among authors: eydoux c. Eur J Med Chem. 2016 Feb 15;109:146-56. doi: 10.1016/j.ejmech.2015.12.046. Epub 2015 Dec 29. Eur J Med Chem. 2016. PMID: 26774922
A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase.
Shannon A, Fattorini V, Sama B, Selisko B, Feracci M, Falcou C, Gauffre P, El Kazzi P, Delpal A, Decroly E, Alvarez K, Eydoux C, Guillemot JC, Moussa A, Good SS, La Colla P, Lin K, Sommadossi JP, Zhu Y, Yan X, Shi H, Ferron F, Canard B. Shannon A, et al. Among authors: eydoux c. Nat Commun. 2022 Feb 2;13(1):621. doi: 10.1038/s41467-022-28113-1. Nat Commun. 2022. PMID: 35110538 Free PMC article.
Identification of allosteric inhibitors blocking the hepatitis C virus polymerase NS5B in the RNA synthesis initiation step.
Betzi S, Eydoux C, Bussetta C, Blemont M, Leyssen P, Debarnot C, Ben-Rahou M, Haiech J, Hibert M, Gueritte F, Grierson DS, Romette JL, Guillemot JC, Neyts J, Alvarez K, Morelli X, Dutartre H, Canard B. Betzi S, et al. Among authors: eydoux c. Antiviral Res. 2009 Oct;84(1):48-59. doi: 10.1016/j.antiviral.2009.06.009. Epub 2009 Jul 7. Antiviral Res. 2009. PMID: 19589358
28 results