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A Novel, Orally Bioavailable, Small-Molecule Inhibitor of PCSK9 With Significant Cholesterol-Lowering Properties In Vivo.
Suchowerska AK, Stokman G, Palmer JT, Coghlan PA, Pieterman EJ, Keijzer N, Lambert G, Chemello K, Jaafar AK, Parmar J, Yan L, Tong Y, Mu L, Princen HMG, Bonnar J, Evison BJ. Suchowerska AK, et al. Among authors: evison bj. J Lipid Res. 2022 Nov;63(11):100293. doi: 10.1016/j.jlr.2022.100293. Epub 2022 Oct 6. J Lipid Res. 2022. PMID: 36209894 Free PMC article.
A small molecule inhibitor of PCSK9 that antagonizes LDL receptor binding via interaction with a cryptic PCSK9 binding groove.
Evison BJ, Palmer JT, Lambert G, Treutlein H, Zeng J, Nativel B, Chemello K, Zhu Q, Wang J, Teng Y, Tang W, Xu Y, Rathi AK, Kumar S, Suchowerska AK, Parmar J, Dixon I, Kelly GE, Bonnar J. Evison BJ, et al. Bioorg Med Chem. 2020 Mar 15;28(6):115344. doi: 10.1016/j.bmc.2020.115344. Epub 2020 Jan 31. Bioorg Med Chem. 2020. PMID: 32051094 Free article.
PCSK9 activation promotes early atherosclerosis in a vascular microphysiological system.
Lee JH, Shores KL, Breithaupt JJ, Lee CS, Fodera DM, Kwon JB, Ettyreddy AR, Myers KM, Evison BJ, Suchowerska AK, Gersbach CA, Leong KW, Truskey GA. Lee JH, et al. Among authors: evison bj. APL Bioeng. 2023 Oct 16;7(4):046103. doi: 10.1063/5.0167440. eCollection 2023 Dec. APL Bioeng. 2023. PMID: 37854060 Free PMC article.
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