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The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase.
Cox TR, Rumney RMH, Schoof EM, Perryman L, Høye AM, Agrawal A, Bird D, Latif NA, Forrest H, Evans HR, Huggins ID, Lang G, Linding R, Gartland A, Erler JT. Cox TR, et al. Among authors: evans hr. Nature. 2015 Jun 4;522(7554):106-110. doi: 10.1038/nature14492. Epub 2015 May 27. Nature. 2015. PMID: 26017313 Free PMC article. Retracted.
LOXL2-mediated matrix remodeling in metastasis and mammary gland involution.
Barker HE, Chang J, Cox TR, Lang G, Bird D, Nicolau M, Evans HR, Gartland A, Erler JT. Barker HE, et al. Among authors: evans hr. Cancer Res. 2011 Mar 1;71(5):1561-72. doi: 10.1158/0008-5472.CAN-10-2868. Epub 2011 Jan 13. Cancer Res. 2011. PMID: 21233336 Free PMC article.
Tasquinimod suppresses tumor cell growth and bone resorption by targeting immunosuppressive myeloid cells and inhibiting c-MYC expression in multiple myeloma.
Fan R, Satilmis H, Vandewalle N, Verheye E, Vlummens P, Maes A, Muylaert C, De Bruyne E, Menu E, Evans H, Chantry A, De Beule N, Hose D, Törngren M, Eriksson H, Vanderkerken K, Maes K, Breckpot K, De Veirman K. Fan R, et al. J Immunother Cancer. 2023 Jan;11(1):e005319. doi: 10.1136/jitc-2022-005319. J Immunother Cancer. 2023. PMID: 36650020 Free PMC article.
Targeting alternative splicing as a new cancer immunotherapy-phosphorylation of serine arginine-rich splicing factor (SRSF1) by SR protein kinase 1 (SRPK1) regulates alternative splicing of PD1 to generate a soluble antagonistic isoform that prevents T cell exhaustion.
Wahid M, Pratoomthai B, Egbuniwe IU, Evans HR, Babaei-Jadidi R, Amartey JO, Erdelyi V, Yacqub-Usman K, Jackson AM, Morris JC, Patel PM, Bates DO. Wahid M, et al. Among authors: evans hr. Cancer Immunol Immunother. 2023 Dec;72(12):4001-4014. doi: 10.1007/s00262-023-03534-z. Epub 2023 Nov 16. Cancer Immunol Immunother. 2023. PMID: 37973660 Free PMC article.
A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension.
Arnold ND, Pickworth JA, West LE, Dawson S, Carvalho JA, Casbolt H, Braithwaite AT, Iremonger J, Renshall L, Germaschewski V, McCourt M, Bland-Ward P, Kowash H, Hameed AG, Rothman AMK, Frid MG, Roger Thompson AA, Evans HR, Southwood M, Morrell NW, Crossman DC, Whyte MKB, Stenmark KR, Newman CM, Kiely DG, Francis SE, Lawrie A. Arnold ND, et al. Among authors: evans hr. Nat Commun. 2019 Nov 15;10(1):5183. doi: 10.1038/s41467-019-13139-9. Nat Commun. 2019. PMID: 31729368 Free PMC article.
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