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BECLIN1 is essential for intestinal homeostasis involving autophagy-independent mechanisms through its function in endocytic trafficking.
Tran S, Juliani J, Harris TJ, Evangelista M, Ratcliffe J, Ellis SL, Baloyan D, Reehorst CM, Nightingale R, Luk IY, Jenkins LJ, Ghilas S, Yakou MH, Inguanti C, Johnson C, Buchert M, Lee JC, De Cruz P, Duszyc K, Gleeson PA, Kile BT, Mielke LA, Yap AS, Mariadason JM, Douglas Fairlie W, Lee EF. Tran S, et al. Among authors: evangelista m. Commun Biol. 2024 Feb 20;7(1):209. doi: 10.1038/s42003-024-05890-7. Commun Biol. 2024. PMID: 38378743 Free PMC article.
Diversity in the intrinsic apoptosis pathway of nematodes.
Young ND, Harris TJ, Evangelista M, Tran S, Wouters MA, Soares da Costa TP, Kershaw NJ, Gasser RB, Smith BJ, Lee EF, Fairlie WD. Young ND, et al. Among authors: evangelista m. Commun Biol. 2020 Aug 28;3(1):478. doi: 10.1038/s42003-020-01208-5. Commun Biol. 2020. PMID: 32859965 Free PMC article.
Structural insights into BCL2 pro-survival protein interactions with the key autophagy regulator BECN1 following phosphorylation by STK4/MST1.
Lee EF, Smith NA, Soares da Costa TP, Meftahi N, Yao S, Harris TJ, Tran S, Pettikiriarachchi A, Perugini MA, Keizer DW, Evangelista M, Smith BJ, Fairlie WD. Lee EF, et al. Among authors: evangelista m. Autophagy. 2019 May;15(5):785-795. doi: 10.1080/15548627.2018.1564557. Epub 2019 Jan 9. Autophagy. 2019. PMID: 30626284 Free PMC article.
BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival.
Lee EF, Harris TJ, Tran S, Evangelista M, Arulananda S, John T, Ramnac C, Hobbs C, Zhu H, Gunasingh G, Segal D, Behren A, Cebon J, Dobrovic A, Mariadason JM, Strasser A, Rohrbeck L, Haass NK, Herold MJ, Fairlie WD. Lee EF, et al. Among authors: evangelista m. Cell Death Dis. 2019 Apr 24;10(5):342. doi: 10.1038/s41419-019-1568-3. Cell Death Dis. 2019. PMID: 31019203 Free PMC article.
BCL-XL is an actionable target for treatment of malignant pleural mesothelioma.
Arulananda S, O'Brien M, Evangelista M, Harris TJ, Steinohrt NS, Jenkins LJ, Walkiewicz M, O'Donoghue RJJ, Poh AR, Thapa B, Williams DS, Leong T, Mariadason JM, Li X, Cebon J, Lee EF, John T, Fairlie WD. Arulananda S, et al. Among authors: evangelista m. Cell Death Discov. 2020 Oct 31;6(1):114. doi: 10.1038/s41420-020-00348-1. Cell Death Discov. 2020. PMID: 33298868 Free PMC article.
Optimization of Benzothiazole and Thiazole Hydrazones as Inhibitors of Schistosome BCL-2.
Nguyen W, Lee EF, Evangelista M, Lee M, Harris TJ, Colman PM, Smith NA, Williams LB, Jarman KE, Lowes KN, Haeberli C, Keiser J, Smith BJ, Fairlie WD, Sleebs BE. Nguyen W, et al. Among authors: evangelista m. ACS Infect Dis. 2021 May 14;7(5):1143-1163. doi: 10.1021/acsinfecdis.0c00700. Epub 2021 Feb 1. ACS Infect Dis. 2021. PMID: 33523649
A novel BH3-mimetic, AZD0466, targeting BCL-XL and BCL-2 is effective in pre-clinical models of malignant pleural mesothelioma.
Arulananda S, O'Brien M, Evangelista M, Jenkins LJ, Poh AR, Walkiewicz M, Leong T, Mariadason JM, Cebon J, Balachander SB, Cidado JR, Lee EF, John T, Fairlie WD. Arulananda S, et al. Among authors: evangelista m. Cell Death Discov. 2021 May 28;7(1):122. doi: 10.1038/s41420-021-00505-0. Cell Death Discov. 2021. PMID: 34050131 Free PMC article.
Correction: BCL-XL is an actionable target for treatment of malignant pleural mesothelioma.
Arulananda S, O'Brien M, Evangelista M, Harris TJ, Steinohrt NS, Jenkins LJ, Walkiewicz M, O'Donoghue RJJ, Poh AR, Thapa B, Williams DS, Leong T, Mariadason JM, Li X, Cebon J, Lee EF, John T, Fairlie WD. Arulananda S, et al. Among authors: evangelista m. Cell Death Discov. 2021 Jun 15;7(1):146. doi: 10.1038/s41420-020-00388-7. Cell Death Discov. 2021. PMID: 34131107 Free PMC article. No abstract available.
Physiological restraint of Bak by Bcl-xL is essential for cell survival.
Lee EF, Grabow S, Chappaz S, Dewson G, Hockings C, Kluck RM, Debrincat MA, Gray DH, Witkowski MT, Evangelista M, Pettikiriarachchi A, Bouillet P, Lane RM, Czabotar PE, Colman PM, Smith BJ, Kile BT, Fairlie WD. Lee EF, et al. Among authors: evangelista m. Genes Dev. 2016 May 15;30(10):1240-50. doi: 10.1101/gad.279414.116. Epub 2016 May 19. Genes Dev. 2016. PMID: 27198225 Free PMC article.
388 results