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Activation of NOX2 by the stimulation of ionotropic and metabotropic glutamate receptors contributes to glutamate neurotoxicity in vivo through the production of reactive oxygen species and calpain activation.
Guemez-Gamboa A, Estrada-Sánchez AM, Montiel T, Páramo B, Massieu L, Morán J. Guemez-Gamboa A, et al. Among authors: estrada sanchez am. J Neuropathol Exp Neurol. 2011 Nov;70(11):1020-35. doi: 10.1097/NEN.0b013e3182358e4e. J Neuropathol Exp Neurol. 2011. PMID: 22002428
Differential effects of the substrate inhibitor l-trans-pyrrolidine-2,4-dicarboxylate (PDC) and the non-substrate inhibitor DL-threo-beta-benzyloxyaspartate (DL-TBOA) of glutamate transporters on neuronal damage and extracellular amino acid levels in rat brain in vivo.
Montiel T, Camacho A, Estrada-Sánchez AM, Massieu L. Montiel T, et al. Among authors: estrada sanchez am. Neuroscience. 2005;133(3):667-78. doi: 10.1016/j.neuroscience.2004.11.020. Neuroscience. 2005. PMID: 15890455
Cortical Network Dynamics Is Altered in Mouse Models of Huntington's Disease.
Donzis EJ, Estrada-Sánchez AM, Indersmitten T, Oikonomou K, Tran CH, Wang C, Latifi S, Golshani P, Cepeda C, Levine MS. Donzis EJ, et al. Among authors: estrada sanchez am. Cereb Cortex. 2020 Apr 14;30(4):2372-2388. doi: 10.1093/cercor/bhz245. Cereb Cortex. 2020. PMID: 31761935 Free PMC article.
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