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2000 11
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2024 10

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551 results

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Page 1
Showing results for ester gp
Search for Esther GP instead (1 results)
Valacyclovir.
Acosta EP, Fletcher CV. Acosta EP, et al. Ann Pharmacother. 1997 Feb;31(2):185-91. doi: 10.1177/106002809703100211. Ann Pharmacother. 1997. PMID: 9034421 Review.
All articles with pertinent information relevant to the scope of this article were reviewed. DATA SYNTHESIS: Valacyclovir is an amino acid ester prodrug of acyclovir. It is currently approved for the treatment of herpes zoster infections in immunocompetent adults (1 g p.o. …
All articles with pertinent information relevant to the scope of this article were reviewed. DATA SYNTHESIS: Valacyclovir is an amino acid …
An ester derivative of tenacigenin B from Marsdenia tenacissima (Roxb.) Wight et Arn reversed paclitaxel-induced MDR in vitro and in vivo by inhibiting both P-gp and MRP2.
Wu ZL, Chen Y, Qu Z, Wu GY, He XF, Huang JW, Meng QQ, Hu YH, Shen XL, Yang RY, Hu YJ. Wu ZL, et al. J Ethnopharmacol. 2022 Aug 10;294:115353. doi: 10.1016/j.jep.2022.115353. Epub 2022 May 6. J Ethnopharmacol. 2022. PMID: 35533911
Moreover, MT2 directly inhibited P-gp-mediated substrate transport while interacting with membrane P-gp in non-substrate ways. ...It impedes membrane drug efflux pumps by suppressing P-gp and MRP2 expression, and directly inhibiting the transport function of …
Moreover, MT2 directly inhibited P-gp-mediated substrate transport while interacting with membrane P-gp in non-substrate ways. …
Dietary ketone ester attenuates the accretion of adiposity and liver steatosis in mice fed a high-fat, high-sugar diet.
Rushing KA, Bolyard ML, Kelty T, Wieschhaus N, Pavela G, Rector RS, Plaisance EP. Rushing KA, et al. Front Physiol. 2023 Apr 11;14:1165224. doi: 10.3389/fphys.2023.1165224. eCollection 2023. Front Physiol. 2023. PMID: 37113697 Free PMC article.
Objective: The ketone diester, R,S-1,3-butanediol diacetoacetate (BD-AcAc(2)), attenuates the accretion of adiposity and reduces hepatic steatosis in high-fat diet-induced obese mice when carbohydrate energy is removed from the diet to accommodate energy from the ester. Re …
Objective: The ketone diester, R,S-1,3-butanediol diacetoacetate (BD-AcAc(2)), attenuates the accretion of adiposity and reduces hepatic ste …
From mouse to human: Accessing the biochemistry of vision in vivo by two-photon excitation.
Palczewska G, Wojtkowski M, Palczewski K. Palczewska G, et al. Prog Retin Eye Res. 2023 Mar;93:101170. doi: 10.1016/j.preteyeres.2023.101170. Epub 2023 Feb 12. Prog Retin Eye Res. 2023. PMID: 36787681 Free PMC article. Review.
The interface between the retina and the retinal pigment epithelium (RPE) is especially informative, because it reflects the health of the visual (retinoid) cycle and its changes in response to external stress, genetic manipulations, and drug treatments. Vitamin A-derived retinoi …
The interface between the retina and the retinal pigment epithelium (RPE) is especially informative, because it reflects the health of the v …
PNPLA3 gene in liver diseases.
Trépo E, Romeo S, Zucman-Rossi J, Nahon P. Trépo E, et al. J Hepatol. 2016 Aug;65(2):399-412. doi: 10.1016/j.jhep.2016.03.011. Epub 2016 Mar 30. J Hepatol. 2016. PMID: 27038645 Review.
The PNPLA3 protein has lipase activity towards triglycerides in hepatocytes and retinyl esters in hepatic stellate cells. The I148M substitution leads to a loss of function promoting triglyceride accumulation in hepatocytes. ...
The PNPLA3 protein has lipase activity towards triglycerides in hepatocytes and retinyl esters in hepatic stellate cells. The I148M s …
Bioconversion and P-gp-Mediated Transport of Depot Fluphenazine Prodrugs after Intramuscular Injection.
Ohura K, Nakada Y, Imai T. Ohura K, et al. J Pharm Sci. 2023 Jul;112(7):1975-1984. doi: 10.1016/j.xphs.2023.03.018. Epub 2023 Apr 4. J Pharm Sci. 2023. PMID: 37019360
Fluphenazine (FPZ) decanoate, an ester-type prodrug formulated as a long-acting injection (LAI), is used in the treatment of schizophrenia. ...
Fluphenazine (FPZ) decanoate, an ester-type prodrug formulated as a long-acting injection (LAI), is used in the treatment of schizoph …
6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers.
Braconi L, Bartolucci G, Contino M, Chiaramonte N, Giampietro R, Manetti D, Perrone MG, Romanelli MN, Colabufo NA, Riganti C, Dei S, Teodori E. Braconi L, et al. J Enzyme Inhib Med Chem. 2020 Dec;35(1):974-992. doi: 10.1080/14756366.2020.1747449. J Enzyme Inhib Med Chem. 2020. PMID: 32253945 Free PMC article.
Aiming to deepen the structure-activity relationships of the two P-glycoprotein (P-gp) modulators elacridar and tariquidar, a new series of amide and ester derivatives carrying a 6,7-dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline scaffold linked to different m …
Aiming to deepen the structure-activity relationships of the two P-glycoprotein (P-gp) modulators elacridar and tariquidar, a new ser …
Simultaneous Delivery of Doxorubicin and Protease Inhibitor Derivative to Solid Tumors via Star-Shaped Polymer Nanomedicines Overcomes P-gp- and STAT3-Mediated Chemoresistance.
Kostka L, Sivák L, Šubr V, Kovářová J, Šírová M, Říhová B, Sedlacek R, Etrych T, Kovář M. Kostka L, et al. Biomacromolecules. 2022 Jun 13;23(6):2522-2535. doi: 10.1021/acs.biomac.2c00256. Epub 2022 May 18. Biomacromolecules. 2022. PMID: 35584053
The derivative of protease inhibitor ritonavir (5-methyl-4-oxohexanoic acid ritonavir ester; RD) was recently recognized as a potent P-gp inhibitor and cancerostatic drug inhibiting the proteasome and STAT3 signaling. ...Importantly, Star-RD + Dox was found to have …
The derivative of protease inhibitor ritonavir (5-methyl-4-oxohexanoic acid ritonavir ester; RD) was recently recognized as a potent …
Injectable pathological microenvironment-responsive anti-inflammatory hydrogels for ameliorating intervertebral disc degeneration.
Liu L, Wang W, Huang L, Xian Y, Ma W, Fan J, Li Y, Liu H, Zheng Z, Wu D. Liu L, et al. Biomaterials. 2024 Apr;306:122509. doi: 10.1016/j.biomaterials.2024.122509. Epub 2024 Feb 13. Biomaterials. 2024. PMID: 38377847
The hydrogel system was prepared by conjugating phenylboronic acid-modified gelatin methacryloyl (GP) with the naturally extracted anti-inflammatory drug epigallocatechin-3-gallate (EGCG) through dynamic boronic esters. ...
The hydrogel system was prepared by conjugating phenylboronic acid-modified gelatin methacryloyl (GP) with the naturally extracted an …
pH-Sensitive Poly(beta-amino ester)s Nanocarriers Facilitate the Inhibition of Drug Resistance in Breast Cancer Cells.
Zhou M, Zhang X, Xie J, Qi R, Lu H, Leporatti S, Chen J, Hu Y. Zhou M, et al. Nanomaterials (Basel). 2018 Nov 19;8(11):952. doi: 10.3390/nano8110952. Nanomaterials (Basel). 2018. PMID: 30463238 Free PMC article.
Stimuli-responsive nanocarriers emerge as a promising tool to overcome MDR. Herein, pH-sensitive poly(beta-amino ester)s polymers (PHP)-based micellar nanoparticles were synthesized for enhanced doxorubicin (DOX) delivery in drug resistant breast cancer MCF-7/ADR cells. .. …
Stimuli-responsive nanocarriers emerge as a promising tool to overcome MDR. Herein, pH-sensitive poly(beta-amino ester)s polymers (PH …
551 results