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BRAF activation by metabolic stress promotes glycolysis sensitizing NRASQ61-mutated melanomas to targeted therapy.
McGrail K, Granado-Martínez P, Esteve-Puig R, García-Ortega S, Ding Y, Sánchez-Redondo S, Ferrer B, Hernandez-Losa J, Canals F, Manzano A, Navarro-Sabaté A, Bartrons R, Yanes O, Pérez-Alea M, Muñoz-Couselo E, Garcia-Patos V, Recio JA. McGrail K, et al. Among authors: esteve puig r. Nat Commun. 2022 Nov 19;13(1):7113. doi: 10.1038/s41467-022-34907-0. Nat Commun. 2022. PMID: 36402789 Free PMC article.
A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation.
Esteve-Puig R, Gil R, González-Sánchez E, Bech-Serra JJ, Grueso J, Hernández-Losa J, Moliné T, Canals F, Ferrer B, Cortés J, Bastian B, Ramón Y Cajal S, Martín-Caballero J, Flores JM, Vivancos A, García-Patos V, Recio JÁ. Esteve-Puig R, et al. PLoS Genet. 2014 Oct 16;10(10):e1004721. doi: 10.1371/journal.pgen.1004721. eCollection 2014 Oct. PLoS Genet. 2014. PMID: 25329316 Free PMC article.
Kinase fusions are frequent in Spitz tumours and spitzoid melanomas.
Wiesner T, He J, Yelensky R, Esteve-Puig R, Botton T, Yeh I, Lipson D, Otto G, Brennan K, Murali R, Garrido M, Miller VA, Ross JS, Berger MF, Sparatta A, Palmedo G, Cerroni L, Busam KJ, Kutzner H, Cronin MT, Stephens PJ, Bastian BC. Wiesner T, et al. Nat Commun. 2014;5:3116. doi: 10.1038/ncomms4116. Nat Commun. 2014. PMID: 24445538 Free PMC article.
Dual MEK/AKT inhibition with trametinib and GSK2141795 does not yield clinical benefit in metastatic NRAS-mutant and wild-type melanoma.
Algazi AP, Esteve-Puig R, Nosrati A, Hinds B, Hobbs-Muthukumar A, Nandoskar P, Ortiz-Urda S, Chapman PB, Daud A. Algazi AP, et al. Among authors: esteve puig r. Pigment Cell Melanoma Res. 2018 Jan;31(1):110-114. doi: 10.1111/pcmr.12644. Epub 2017 Nov 2. Pigment Cell Melanoma Res. 2018. PMID: 28921907 Free PMC article. Clinical Trial.
Phosphoproteomic Analyses of NRAS(G12) and NRAS(Q61) Mutant Melanocytes Reveal Increased CK2α Kinase Levels in NRAS(Q61) Mutant Cells.
Posch C, Sanlorenzo M, Vujic I, Oses-Prieto JA, Cholewa BD, Kim ST, Ma J, Lai K, Zekhtser M, Esteve-Puig R, Green G, Chand S, Burlingame AL, Panzer-Grümayer R, Rappersberger K, Ortiz-Urda S. Posch C, et al. Among authors: esteve puig r. J Invest Dermatol. 2016 Oct;136(10):2041-2048. doi: 10.1016/j.jid.2016.05.098. Epub 2016 May 29. J Invest Dermatol. 2016. PMID: 27251789 Free PMC article.
The lincRNA MIRAT binds to IQGAP1 and modulates the MAPK pathway in NRAS mutant melanoma.
Sanlorenzo M, Vujic I, Esteve-Puig R, Lai K, Vujic M, Lin K, Posch C, Dimon M, Moy A, Zekhtser M, Johnston K, Gho D, Ho W, Gajjala A, Oses Prieto J, Burlingame A, Daud A, Rappersberger K, Ortiz-Urda S. Sanlorenzo M, et al. Among authors: esteve puig r. Sci Rep. 2018 Jul 19;8(1):10902. doi: 10.1038/s41598-018-27643-3. Sci Rep. 2018. PMID: 30026510 Free PMC article.
14 results