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Vaccination with the recombinant Brucella outer membrane protein 31 or a derived 27-amino-acid synthetic peptide elicits a CD4+ T helper 1 response that protects against Brucella melitensis infection.
Cassataro J, Estein SM, Pasquevich KA, Velikovsky CA, de la Barrera S, Bowden R, Fossati CA, Giambartolomei GH. Cassataro J, et al. Among authors: estein sm. Infect Immun. 2005 Dec;73(12):8079-88. doi: 10.1128/IAI.73.12.8079-8088.2005. Infect Immun. 2005. PMID: 16299302 Free PMC article.
Improved immunogenicity of a vaccination regimen combining a DNA vaccine encoding Brucella melitensis outer membrane protein 31 (Omp31) and recombinant Omp31 boosting.
Cassataro J, Velikovsky CA, Bruno L, Estein SM, de la Barrera S, Bowden R, Fossati CA, Giambartolomei GH. Cassataro J, et al. Among authors: estein sm. Clin Vaccine Immunol. 2007 Jul;14(7):869-74. doi: 10.1128/CVI.00472-06. Epub 2007 Apr 11. Clin Vaccine Immunol. 2007. PMID: 17428946 Free PMC article.
Immunization with recombinant Brucella species outer membrane protein Omp16 or Omp19 in adjuvant induces specific CD4+ and CD8+ T cells as well as systemic and oral protection against Brucella abortus infection.
Pasquevich KA, Estein SM, García Samartino C, Zwerdling A, Coria LM, Barrionuevo P, Fossati CA, Giambartolomei GH, Cassataro J. Pasquevich KA, et al. Among authors: estein sm. Infect Immun. 2009 Jan;77(1):436-45. doi: 10.1128/IAI.01151-08. Epub 2008 Nov 3. Infect Immun. 2009. PMID: 18981242 Free PMC article.
The protein moiety of Brucella abortus outer membrane protein 16 is a new bacterial pathogen-associated molecular pattern that activates dendritic cells in vivo, induces a Th1 immune response, and is a promising self-adjuvanting vaccine against systemic and oral acquired brucellosis.
Pasquevich KA, García Samartino C, Coria LM, Estein SM, Zwerdling A, Ibañez AE, Barrionuevo P, Oliveira FS, Carvalho NB, Borkowski J, Oliveira SC, Warzecha H, Giambartolomei GH, Cassataro J. Pasquevich KA, et al. Among authors: estein sm. J Immunol. 2010 May 1;184(9):5200-12. doi: 10.4049/jimmunol.0902209. Epub 2010 Mar 29. J Immunol. 2010. PMID: 20351187
An oral vaccine based on U-Omp19 induces protection against B. abortus mucosal challenge by inducing an adaptive IL-17 immune response in mice.
Pasquevich KA, Ibañez AE, Coria LM, García Samartino C, Estein SM, Zwerdling A, Barrionuevo P, Oliveira FS, Seither C, Warzecha H, Oliveira SC, Giambartolomei GH, Cassataro J. Pasquevich KA, et al. Among authors: estein sm. PLoS One. 2011 Jan 14;6(1):e16203. doi: 10.1371/journal.pone.0016203. PLoS One. 2011. PMID: 21264260 Free PMC article.
Immune response and serum bactericidal activity against Brucella ovis elicited using a short immunization schedule with the polymeric antigen BLSOmp31 in rams.
Díaz AG, Clausse M, Paolicchi FA, Fiorentino MA, Ghersi G, Zylberman V, Goldbaum FA, Estein SM. Díaz AG, et al. Among authors: estein sm. Vet Immunol Immunopathol. 2013 Jul 15;154(1-2):36-41. doi: 10.1016/j.vetimm.2013.04.003. Epub 2013 Apr 11. Vet Immunol Immunopathol. 2013. PMID: 23643287 Clinical Trial.
Immune response induced by conjunctival immunization with polymeric antigen BLSOmp31 using a thermoresponsive and mucoadhesive in situ gel as vaccine delivery system for prevention of ovine brucellosis.
Díaz AG, Quinteros DA, Gutiérrez SE, Rivero MA, Palma SD, Allemandi DA, Pardo RP, Zylberman V, Goldbaum FA, Estein SM. Díaz AG, et al. Among authors: estein sm. Vet Immunol Immunopathol. 2016 Oct 1;178:50-6. doi: 10.1016/j.vetimm.2016.07.004. Epub 2016 Jul 5. Vet Immunol Immunopathol. 2016. PMID: 27496742
45 results