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Chemical intervention of influenza virus mRNA nuclear export.
Esparza M, Mor A, Niederstrasser H, White K, White A, Zhang K, Gao S, Wang J, Liang J, Sho S, Sakthivel R, Sathe AA, Xing C, Muñoz-Moreno R, Shay JW, García-Sastre A, Ready J, Posner B, Fontoura BMA. Esparza M, et al. PLoS Pathog. 2020 Apr 2;16(4):e1008407. doi: 10.1371/journal.ppat.1008407. eCollection 2020 Apr. PLoS Pathog. 2020. PMID: 32240278 Free PMC article.
Influenza virus mRNA trafficking through host nuclear speckles.
Mor A, White A, Zhang K, Thompson M, Esparza M, Muñoz-Moreno R, Koide K, Lynch KW, García-Sastre A, Fontoura BM. Mor A, et al. Among authors: esparza m. Nat Microbiol. 2016 May 27;1(7):16069. doi: 10.1038/nmicrobiol.2016.69. Nat Microbiol. 2016. PMID: 27572970 Free PMC article.
Corrigendum: Influenza virus mRNA trafficking through host nuclear speckles.
Mor A, White A, Zhang K, Thompson M, Esparza M, Muñoz-Moreno R, Koide K, Lynch KW, García-Sastre A, Fontoura BM. Mor A, et al. Among authors: esparza m. Nat Microbiol. 2017 Jan 9;2:17002. doi: 10.1038/nmicrobiol.2017.2. Nat Microbiol. 2017. PMID: 28067239 No abstract available.
Structural basis for influenza virus NS1 protein block of mRNA nuclear export.
Zhang K, Xie Y, Muñoz-Moreno R, Wang J, Zhang L, Esparza M, García-Sastre A, Fontoura BMA, Ren Y. Zhang K, et al. Among authors: esparza m. Nat Microbiol. 2019 Oct;4(10):1671-1679. doi: 10.1038/s41564-019-0482-x. Epub 2019 Jul 1. Nat Microbiol. 2019. PMID: 31263181 Free PMC article.
Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression.
Zhang K, Miorin L, Makio T, Dehghan I, Gao S, Xie Y, Zhong H, Esparza M, Kehrer T, Kumar A, Hobman TC, Ptak C, Gao B, Minna JD, Chen Z, García-Sastre A, Ren Y, Wozniak RW, Fontoura BMA. Zhang K, et al. Among authors: esparza m. Sci Adv. 2021 Feb 5;7(6):eabe7386. doi: 10.1126/sciadv.abe7386. Print 2021 Feb. Sci Adv. 2021. PMID: 33547084 Free PMC article.
Aryl Sulfonamide Inhibits Entry and Replication of Diverse Influenza Viruses via the Hemagglutinin Protein.
White K, Esparza M, Liang J, Bhat P, Naidoo J, McGovern BL, Williams MAP, Alabi BR, Shay J, Niederstrasser H, Posner B, García-Sastre A, Ready J, Fontoura BMA. White K, et al. Among authors: esparza m. J Med Chem. 2021 Aug 12;64(15):10951-10966. doi: 10.1021/acs.jmedchem.1c00304. Epub 2021 Jul 14. J Med Chem. 2021. PMID: 34260245 Free PMC article.
Nuclear speckle integrity and function require TAO2 kinase.
Gao S, Esparza M, Dehghan I, Aksenova V, Zhang K, Batten K, Ferretti MB, Begg BE, Cagatay T, Shay JW, García-Sastre A, Goldsmith EJ, Chen ZJ, Dasso M, Lynch KW, Cobb MH, Fontoura BMA. Gao S, et al. Among authors: esparza m. Proc Natl Acad Sci U S A. 2022 Jun 21;119(25):e2206046119. doi: 10.1073/pnas.2206046119. Epub 2022 Jun 15. Proc Natl Acad Sci U S A. 2022. PMID: 35704758 Free PMC article.
Influenza virus mRNAs encode determinants for nuclear export via the cellular TREX-2 complex.
Bhat P, Aksenova V, Gazzara M, Rex EA, Aslam S, Haddad C, Gao S, Esparza M, Cagatay T, Batten K, El Zahed SS, Arnaoutov A, Zhong H, Shay JW, Tolbert BS, Dasso M, Lynch KW, García-Sastre A, Fontoura BMA. Bhat P, et al. Among authors: esparza m. Nat Commun. 2023 Apr 21;14(1):2304. doi: 10.1038/s41467-023-37911-0. Nat Commun. 2023. PMID: 37085480 Free PMC article.
158 results