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Metabolic reprogramming by Acly inhibition using SB-204990 alters glucoregulation and modulates molecular mechanisms associated with aging.
Sola-García A, Cáliz-Molina MÁ, Espadas I, Petr M, Panadero-Morón C, González-Morán D, Martín-Vázquez ME, Narbona-Pérez ÁJ, López-Noriega L, Martínez-Corrales G, López-Fernández-Sobrino R, Carmona-Marin LM, Martínez-Force E, Yanes O, Vinaixa M, López-López D, Reyes JC, Dopazo J, Martín F, Gauthier BR, Scheibye-Knudsen M, Capilla-González V, Martín-Montalvo A. Sola-García A, et al. Among authors: espadas i. Commun Biol. 2023 Mar 8;6(1):250. doi: 10.1038/s42003-023-04625-4. Commun Biol. 2023. PMID: 36890357 Free PMC article.
Impaired Plakophilin-2 in obesity breaks cell cycle dynamics to breed adipocyte senescence.
Lluch A, Latorre J, Serena-Maione A, Espadas I, Caballano-Infantes E, Moreno-Navarrete JM, Oliveras-Cañellas N, Ricart W, Malagón MM, Martin-Montalvo A, Birchmeier W, Szymanski W, Graumann J, Gómez-Serrano M, Sommariva E, Fernández-Real JM, Ortega FJ. Lluch A, et al. Among authors: espadas i. Nat Commun. 2023 Aug 22;14(1):5106. doi: 10.1038/s41467-023-40596-0. Nat Commun. 2023. PMID: 37607954 Free PMC article.
N370S-GBA1 mutation causes lysosomal cholesterol accumulation in Parkinson's disease.
García-Sanz P, Orgaz L, Bueno-Gil G, Espadas I, Rodríguez-Traver E, Kulisevsky J, Gutierrez A, Dávila JC, González-Polo RA, Fuentes JM, Mir P, Vicario C, Moratalla R. García-Sanz P, et al. Among authors: espadas i. Mov Disord. 2017 Oct;32(10):1409-1422. doi: 10.1002/mds.27119. Epub 2017 Aug 5. Mov Disord. 2017. PMID: 28779532
23 results