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Multiplex genome editing of mammalian cells for producing recombinant heparin.
Thacker BE, Thorne KJ, Cartwright C, Park J, Glass K, Chea A, Kellman BP, Lewis NE, Wang Z, Di Nardo A, Sharfstein ST, Jeske W, Walenga J, Hogwood J, Gray E, Mulloy B, Esko JD, Glass CA. Thacker BE, et al. Among authors: esko jd. Metab Eng. 2022 Mar;70:155-165. doi: 10.1016/j.ymben.2022.01.002. Epub 2022 Jan 14. Metab Eng. 2022. PMID: 35038554 Free article.
ZNF263 is a transcriptional regulator of heparin and heparan sulfate biosynthesis.
Weiss RJ, Spahn PN, Toledo AG, Chiang AWT, Kellman BP, Li J, Benner C, Glass CK, Gordts PLSM, Lewis NE, Esko JD. Weiss RJ, et al. Among authors: esko jd. Proc Natl Acad Sci U S A. 2020 Apr 28;117(17):9311-9317. doi: 10.1073/pnas.1920880117. Epub 2020 Apr 10. Proc Natl Acad Sci U S A. 2020. PMID: 32277030 Free PMC article.
SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2.
Clausen TM, Sandoval DR, Spliid CB, Pihl J, Perrett HR, Painter CD, Narayanan A, Majowicz SA, Kwong EM, McVicar RN, Thacker BE, Glass CA, Yang Z, Torres JL, Golden GJ, Bartels PL, Porell RN, Garretson AF, Laubach L, Feldman J, Yin X, Pu Y, Hauser BM, Caradonna TM, Kellman BP, Martino C, Gordts PLSM, Chanda SK, Schmidt AG, Godula K, Leibel SL, Jose J, Corbett KD, Ward AB, Carlin AF, Esko JD. Clausen TM, et al. Among authors: esko jd. Cell. 2020 Nov 12;183(4):1043-1057.e15. doi: 10.1016/j.cell.2020.09.033. Epub 2020 Sep 14. Cell. 2020. PMID: 32970989 Free PMC article.
Surfen, a small molecule antagonist of heparan sulfate.
Schuksz M, Fuster MM, Brown JR, Crawford BE, Ditto DP, Lawrence R, Glass CA, Wang L, Tor Y, Esko JD. Schuksz M, et al. Among authors: esko jd. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13075-80. doi: 10.1073/pnas.0805862105. Epub 2008 Aug 25. Proc Natl Acad Sci U S A. 2008. PMID: 18725627 Free PMC article.
A Systems View of the Heparan Sulfate Interactome.
Gómez Toledo A, Sorrentino JT, Sandoval DR, Malmström J, Lewis NE, Esko JD. Gómez Toledo A, et al. Among authors: esko jd. J Histochem Cytochem. 2021 Feb;69(2):105-119. doi: 10.1369/0022155420988661. J Histochem Cytochem. 2021. PMID: 33494649 Free PMC article. Review.
Bioengineering murine mastocytoma cells to produce anticoagulant heparin.
Gasimli L, Glass CA, Datta P, Yang B, Li G, Gemmill TR, Baik JY, Sharfstein ST, Esko JD, Linhardt RJ. Gasimli L, et al. Among authors: esko jd. Glycobiology. 2014 Mar;24(3):272-80. doi: 10.1093/glycob/cwt108. Epub 2013 Dec 9. Glycobiology. 2014. PMID: 24326668 Free PMC article.
As reported, MST cells produce a highly sulfated HP-like polysaccharide that lacks anticoagulant activity (Montgomery RI, Lidholt K, Flay NW, Liang J, Vertel B, Lindahl U, Esko JD. 1992. Stable heparin-producing cell lines derived from the Furth murine mastocytoma. …
As reported, MST cells produce a highly sulfated HP-like polysaccharide that lacks anticoagulant activity (Montgomery RI, Lidholt K, Flay NW …
425 results