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Alcohol-preferring rats show decreased corticotropin-releasing hormone-2 receptor expression and differences in HPA activation compared to alcohol-nonpreferring rats.
Yong W, Spence JP, Eskay R, Fitz SD, Damadzic R, Lai D, Foroud T, Carr LG, Shekhar A, Chester JA, Heilig M, Liang T. Yong W, et al. Among authors: eskay r. Alcohol Clin Exp Res. 2014 May;38(5):1275-83. doi: 10.1111/acer.12379. Epub 2014 Mar 10. Alcohol Clin Exp Res. 2014. PMID: 24611993 Free PMC article.
A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats.
Thorsell A, Tapocik JD, Liu K, Zook M, Bell L, Flanigan M, Patnaik S, Marugan J, Damadzic R, Dehdashti SJ, Schwandt ML, Southall N, Austin CP, Eskay R, Ciccocioppo R, Zheng W, Heilig M. Thorsell A, et al. Among authors: eskay r. J Neurosci. 2013 Jun 12;33(24):10132-42. doi: 10.1523/JNEUROSCI.4742-12.2013. J Neurosci. 2013. PMID: 23761908 Free PMC article.
Tacr1 gene variation and neurokinin 1 receptor expression is associated with antagonist efficacy in genetically selected alcohol-preferring rats.
Schank JR, Tapocik JD, Barbier E, Damadzic R, Eskay RL, Sun H, Rowe KE, King CE, Yao M, Flanigan ME, Solomon MG, Karlsson C, Cheng K, Rice KC, Heilig M. Schank JR, et al. Among authors: eskay rl. Biol Psychiatry. 2013 Apr 15;73(8):774-81. doi: 10.1016/j.biopsych.2012.12.027. Epub 2013 Feb 16. Biol Psychiatry. 2013. PMID: 23419547 Free PMC article.
Pharmacological blockade of corticotropin-releasing hormone receptor 1 (CRH1R) reduces voluntary consumption of high alcohol concentrations in non-dependent Wistar rats.
Cippitelli A, Damadzic R, Singley E, Thorsell A, Ciccocioppo R, Eskay RL, Heilig M. Cippitelli A, et al. Among authors: eskay rl. Pharmacol Biochem Behav. 2012 Jan;100(3):522-9. doi: 10.1016/j.pbb.2011.10.016. Epub 2011 Oct 20. Pharmacol Biochem Behav. 2012. PMID: 22036774 Free PMC article.
Identification of Small Molecule Antagonists of the Neuropeptide-S Receptor.
Patnaik S, Marugan J, Liu K, Zheng W, Thorsell A, Eskay R, Southall N, Heilig M, Inglese J, Austin C. Patnaik S, et al. Among authors: eskay r. 2010 Mar 19 [updated 2010 Dec 16]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. 2010 Mar 19 [updated 2010 Dec 16]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. PMID: 21433397 Free Books & Documents. Review.
Identification of Functionally Selective Small Molecule Antagonists of the Neuropeptide-S Receptor: Naphthopyranopyrimidines.
Marugan J, Liu K, Zheng W, Eskay R, Southall N, Heilig M, Inglese J, Austin C. Marugan J, et al. Among authors: eskay r. 2009 Feb 13 [updated 2010 Sep 2]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. 2009 Feb 13 [updated 2010 Sep 2]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. PMID: 21433374 Free Books & Documents. Review.
A genetic determinant of the striatal dopamine response to alcohol in men.
Ramchandani VA, Umhau J, Pavon FJ, Ruiz-Velasco V, Margas W, Sun H, Damadzic R, Eskay R, Schoor M, Thorsell A, Schwandt ML, Sommer WH, George DT, Parsons LH, Herscovitch P, Hommer D, Heilig M. Ramchandani VA, et al. Among authors: eskay r. Mol Psychiatry. 2011 Aug;16(8):809-17. doi: 10.1038/mp.2010.56. Epub 2010 May 18. Mol Psychiatry. 2011. PMID: 20479755 Free PMC article. Clinical Trial.
111 results