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Combination of the PI3K inhibitor Idelalisib with the conventional cytostatics cytarabine and dexamethasone leads to changes in pathway activation that induce anti-proliferative effects in B lymphoblastic leukaemia cell lines.
Sklarz LM, Gladbach YS, Ernst M, Hamed M, Roolf C, Sender S, Beck J, Schütz E, Fischer S, Struckmann S, Junghanss C, Fuellen G, Murua Escobar H. Sklarz LM, et al. Among authors: ernst m. Cancer Cell Int. 2020 Aug 12;20:390. doi: 10.1186/s12935-020-01431-4. eCollection 2020. Cancer Cell Int. 2020. PMID: 32817744 Free PMC article.
Scoring functions for drug-effect similarity.
Struckmann S, Ernst M, Fischer S, Mah N, Fuellen G, Möller S. Struckmann S, et al. Among authors: ernst m. Brief Bioinform. 2021 May 20;22(3):bbaa072. doi: 10.1093/bib/bbaa072. Brief Bioinform. 2021. PMID: 32484516 Free PMC article. Review.
Proteostasis regulators modulate proteasomal activity and gene expression to attenuate multiple phenotypes in Fabry disease.
Seemann S, Ernst M, Cimmaruta C, Struckmann S, Cozma C, Koczan D, Knospe AM, Haake LR, Citro V, Bräuer AU, Andreotti G, Cubellis MV, Fuellen G, Hermann A, Giese AK, Rolfs A, Lukas J. Seemann S, et al. Among authors: ernst m. Biochem J. 2020 Jan 31;477(2):359-380. doi: 10.1042/BCJ20190513. Biochem J. 2020. PMID: 31899485 Free PMC article.
ADAM23 promotes neuronal differentiation of human neural progenitor cells.
Markus-Koch A, Schmitt O, Seemann S, Lukas J, Koczan D, Ernst M, Fuellen G, Wree A, Rolfs A, Luo J. Markus-Koch A, et al. Among authors: ernst m. Cell Mol Biol Lett. 2017 Aug 18;22:16. doi: 10.1186/s11658-017-0045-1. eCollection 2017. Cell Mol Biol Lett. 2017. PMID: 28828010 Free PMC article.
2,151 results