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FimH antagonists for the oral treatment of urinary tract infections: from design and synthesis to in vitro and in vivo evaluation.
Klein T, Abgottspon D, Wittwer M, Rabbani S, Herold J, Jiang X, Kleeb S, Lüthi C, Scharenberg M, Bezençon J, Gubler E, Pang L, Smiesko M, Cutting B, Schwardt O, Ernst B. Klein T, et al. Among authors: ernst b. J Med Chem. 2010 Dec 23;53(24):8627-41. doi: 10.1021/jm101011y. Epub 2010 Nov 24. J Med Chem. 2010. PMID: 21105658
Pre-organization of the core structure of E-selectin antagonists.
Schwizer D, Patton JT, Cutting B, Smieško M, Wagner B, Kato A, Weckerle C, Binder FP, Rabbani S, Schwardt O, Magnani JL, Ernst B. Schwizer D, et al. Among authors: ernst b. Chemistry. 2012 Jan 27;18(5):1342-51. doi: 10.1002/chem.201102884. Epub 2011 Dec 30. Chemistry. 2012. PMID: 22213563
FimH antagonists: bioisosteres to improve the in vitro and in vivo PK/PD profile.
Kleeb S, Pang L, Mayer K, Eris D, Sigl A, Preston RC, Zihlmann P, Sharpe T, Jakob RP, Abgottspon D, Hutter AS, Scharenberg M, Jiang X, Navarra G, Rabbani S, Smiesko M, Lüdin N, Bezençon J, Schwardt O, Maier T, Ernst B. Kleeb S, et al. Among authors: ernst b. J Med Chem. 2015 Mar 12;58(5):2221-39. doi: 10.1021/jm501524q. Epub 2015 Feb 20. J Med Chem. 2015. PMID: 25666045
FimH Antagonists: Phosphate Prodrugs Improve Oral Bioavailability.
Kleeb S, Jiang X, Frei P, Sigl A, Bezençon J, Bamberger K, Schwardt O, Ernst B. Kleeb S, et al. Among authors: ernst b. J Med Chem. 2016 Apr 14;59(7):3163-82. doi: 10.1021/acs.jmedchem.5b01923. Epub 2016 Mar 18. J Med Chem. 2016. PMID: 26959338
Activities of N,N'-Diarylurea MMV665852 analogs against Schistosoma mansoni.
Cowan N, Dätwyler P, Ernst B, Wang C, Vennerstrom JL, Spangenberg T, Keiser J. Cowan N, et al. Among authors: ernst b. Antimicrob Agents Chemother. 2015 Apr;59(4):1935-41. doi: 10.1128/AAC.04463-14. Epub 2015 Jan 12. Antimicrob Agents Chemother. 2015. PMID: 25583726 Free PMC article.
431 results