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Comparative Functional Alanine Positional Scanning of the α-Melanocyte Stimulating Hormone and NDP-Melanocyte Stimulating Hormone Demonstrates Differential Structure-Activity Relationships at the Mouse Melanocortin Receptors.
Todorovic A, Ericson MD, Palusak RD, Sorensen NB, Wood MS, Xiang Z, Haskell-Luevano C. Todorovic A, et al. Among authors: ericson md. ACS Chem Neurosci. 2016 Jul 20;7(7):984-94. doi: 10.1021/acschemneuro.6b00098. Epub 2016 May 17. ACS Chem Neurosci. 2016. PMID: 27135265 Free PMC article.
Bench-top to clinical therapies: A review of melanocortin ligands from 1954 to 2016.
Ericson MD, Lensing CJ, Fleming KA, Schlasner KN, Doering SR, Haskell-Luevano C. Ericson MD, et al. Biochim Biophys Acta Mol Basis Dis. 2017 Oct;1863(10 Pt A):2414-2435. doi: 10.1016/j.bbadis.2017.03.020. Epub 2017 Mar 29. Biochim Biophys Acta Mol Basis Dis. 2017. PMID: 28363699 Free PMC article. Review.
Structure-Activity Relationship Studies on a Macrocyclic Agouti-Related Protein (AGRP) Scaffold Reveal Agouti Signaling Protein (ASP) Residue Substitutions Maintain Melanocortin-4 Receptor Antagonist Potency and Result in Inverse Agonist Pharmacology at the Melanocortin-5 Receptor.
Ericson MD, Freeman KT, Schnell SM, Fleming KA, Haskell-Luevano C. Ericson MD, et al. J Med Chem. 2017 Oct 12;60(19):8103-8114. doi: 10.1021/acs.jmedchem.7b00856. Epub 2017 Oct 4. J Med Chem. 2017. PMID: 28813605 Free PMC article.
Structure-Activity Relationship Studies of a Macrocyclic AGRP-Mimetic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-DPro] Yield Potent and Selective Melanocortin-4 Receptor Antagonists and Melanocortin-5 Receptor Inverse Agonists That Increase Food Intake in Mice.
Fleming KA, Ericson MD, Freeman KT, Adank DN, Lunzer MM, Wilber SL, Haskell-Luevano C. Fleming KA, et al. Among authors: ericson md. ACS Chem Neurosci. 2018 May 16;9(5):1141-1151. doi: 10.1021/acschemneuro.7b00495. Epub 2018 Feb 13. ACS Chem Neurosci. 2018. PMID: 29363944 Free PMC article.
Human β-Defensin 1 and β-Defensin 3 (Mouse Ortholog mBD14) Function as Full Endogenous Agonists at Select Melanocortin Receptors.
Ericson MD, Singh A, Tala SR, Haslach EM, Dirain MLS, Schaub JW, Flores V, Eick N, Lensing CJ, Freeman KT, Smeester BA, Adank DN, Wilber SL, Speth R, Haskell-Luevano C. Ericson MD, et al. J Med Chem. 2018 Apr 26;61(8):3738-3744. doi: 10.1021/acs.jmedchem.8b00251. Epub 2018 Apr 9. J Med Chem. 2018. PMID: 29578343 Free PMC article.
32 results