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Discovery and Optimization of a Compound Series Active against Trypanosoma cruzi, the Causative Agent of Chagas Disease.
Harrison JR, Sarkar S, Hampton S, Riley J, Stojanovski L, Sahlberg C, Appelqvist P, Erath J, Mathan V, Rodriguez A, Kaiser M, Pacanowska DG, Read KD, Johansson NG, Gilbert IH. Harrison JR, et al. Among authors: erath j. J Med Chem. 2020 Mar 26;63(6):3066-3089. doi: 10.1021/acs.jmedchem.9b01852. Epub 2020 Mar 5. J Med Chem. 2020. PMID: 32134269
Antitrypanosomal lead discovery: identification of a ligand-efficient inhibitor of Trypanosoma cruzi CYP51 and parasite growth.
Andriani G, Amata E, Beatty J, Clements Z, Coffey BJ, Courtemanche G, Devine W, Erath J, Juda CE, Wawrzak Z, Wood JT, Lepesheva GI, Rodriguez A, Pollastri MP. Andriani G, et al. Among authors: erath j. J Med Chem. 2013 Mar 28;56(6):2556-67. doi: 10.1021/jm400012e. Epub 2013 Mar 13. J Med Chem. 2013. PMID: 23448316 Free PMC article.
Anilinoquinoline based inhibitors of trypanosomatid proliferation.
Ferrins L, Sharma A, Thomas SM, Mehta N, Erath J, Tanghe S, Leed SE, Rodriguez A, Mensa-Wilmot K, Sciotti RJ, Gillingwater K, Pollastri MP. Ferrins L, et al. Among authors: erath j. PLoS Negl Trop Dis. 2018 Nov 26;12(11):e0006834. doi: 10.1371/journal.pntd.0006834. eCollection 2018 Nov. PLoS Negl Trop Dis. 2018. PMID: 30475800 Free PMC article.
Series of Alkynyl-Substituted Thienopyrimidines as Inhibitors of Protozoan Parasite Proliferation.
Woodring JL, Behera R, Sharma A, Wiedeman J, Patel G, Singh B, Guyett P, Amata E, Erath J, Roncal N, Penn E, Leed SE, Rodriguez A, Sciotti RJ, Mensa-Wilmot K, Pollastri MP. Woodring JL, et al. Among authors: erath j. ACS Med Chem Lett. 2018 Sep 4;9(10):996-1001. doi: 10.1021/acsmedchemlett.8b00245. eCollection 2018 Oct 11. ACS Med Chem Lett. 2018. PMID: 30344906 Free PMC article.
Scaffold and Parasite Hopping: Discovery of New Protozoal Proliferation Inhibitors.
Singh B, Bernatchez JA, McCall LI, Calvet CM, Ackermann J, Souza JM, Thomas D, Silva EM, Bachovchin KA, Klug DM, Jalani HB, Bag S, Buskes MJ, Leed SE, Roncal NE, Penn EC, Erath J, Rodriguez A, Sciotti RJ, Campbell RF, McKerrow J, Siqueira-Neto JL, Ferrins L, Pollastri MP. Singh B, et al. Among authors: erath j. ACS Med Chem Lett. 2020 Jan 10;11(3):249-257. doi: 10.1021/acsmedchemlett.9b00453. eCollection 2020 Mar 12. ACS Med Chem Lett. 2020. PMID: 32184953 Free PMC article.
Corrigendum to "Optimization of physicochemical properties for 4-Anilinoquinazoline inhibitors of trypanosome proliferation" [Eur. J. Med. Chem. 141 (2017) 446-459].
Woodring JL, Bachovchin KA, Brady KG, Gallerstein MF, Erath J, Tanghe S, Leed SE, Rodriguez A, Mensa-Wilmot K, Sciotti RJ, Pollastri MP. Woodring JL, et al. Among authors: erath j. Eur J Med Chem. 2018 May 25;152:515. doi: 10.1016/j.ejmech.2018.05.002. Epub 2018 May 10. Eur J Med Chem. 2018. PMID: 29754075 No abstract available.
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