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High-protein diets increase cardiovascular risk by activating macrophage mTOR to suppress mitophagy.
Zhang X, Sergin I, Evans TD, Jeong SJ, Rodriguez-Velez A, Kapoor D, Chen S, Song E, Holloway KB, Crowley JR, Epelman S, Weihl CC, Diwan A, Fan D, Mittendorfer B, Stitziel NO, Schilling JD, Lodhi IJ, Razani B. Zhang X, et al. Among authors: epelman s. Nat Metab. 2020 Jan;2(1):110-125. doi: 10.1038/s42255-019-0162-4. Epub 2020 Jan 23. Nat Metab. 2020. PMID: 32128508 Free PMC article.
Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation.
Epelman S, Lavine KJ, Beaudin AE, Sojka DK, Carrero JA, Calderon B, Brija T, Gautier EL, Ivanov S, Satpathy AT, Schilling JD, Schwendener R, Sergin I, Razani B, Forsberg EC, Yokoyama WM, Unanue ER, Colonna M, Randolph GJ, Mann DL. Epelman S, et al. Immunity. 2014 Jan 16;40(1):91-104. doi: 10.1016/j.immuni.2013.11.019. Immunity. 2014. PMID: 24439267 Free PMC article.
Induction of lysosomal biogenesis in atherosclerotic macrophages can rescue lipid-induced lysosomal dysfunction and downstream sequelae.
Emanuel R, Sergin I, Bhattacharya S, Turner J, Epelman S, Settembre C, Diwan A, Ballabio A, Razani B. Emanuel R, et al. Among authors: epelman s. Arterioscler Thromb Vasc Biol. 2014 Sep;34(9):1942-1952. doi: 10.1161/ATVBAHA.114.303342. Epub 2014 Jul 24. Arterioscler Thromb Vasc Biol. 2014. PMID: 25060788 Free PMC article.
Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis.
Sergin I, Evans TD, Zhang X, Bhattacharya S, Stokes CJ, Song E, Ali S, Dehestani B, Holloway KB, Micevych PS, Javaheri A, Crowley JR, Ballabio A, Schilling JD, Epelman S, Weihl CC, Diwan A, Fan D, Zayed MA, Razani B. Sergin I, et al. Among authors: epelman s. Nat Commun. 2017 Jun 7;8:15750. doi: 10.1038/ncomms15750. Nat Commun. 2017. PMID: 28589926 Free PMC article.
Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction.
Dick SA, Macklin JA, Nejat S, Momen A, Clemente-Casares X, Althagafi MG, Chen J, Kantores C, Hosseinzadeh S, Aronoff L, Wong A, Zaman R, Barbu I, Besla R, Lavine KJ, Razani B, Ginhoux F, Husain M, Cybulsky MI, Robbins CS, Epelman S. Dick SA, et al. Among authors: epelman s. Nat Immunol. 2019 Jan;20(1):29-39. doi: 10.1038/s41590-018-0272-2. Epub 2018 Dec 11. Nat Immunol. 2019. PMID: 30538339 Free PMC article.
Publisher Correction: Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction.
Dick SA, Macklin JA, Nejat S, Momen A, Clemente-Casares X, Althagafi MG, Chen J, Kantores C, Hosseinzadeh S, Aronoff L, Wong A, Zaman R, Barbu I, Besla R, Lavine KJ, Razani B, Ginhoux F, Husain M, Cybulsky MI, Robbins CS, Epelman S. Dick SA, et al. Among authors: epelman s. Nat Immunol. 2019 May;20(5):664. doi: 10.1038/s41590-019-0363-8. Nat Immunol. 2019. PMID: 30862954
Author Correction: High-protein diets increase cardiovascular risk by activating macrophage mTOR to suppress mitophagy.
Zhang X, Sergin I, Evans TD, Jeong SJ, Rodriguez-Velez A, Kapoor D, Chen S, Song E, Holloway KB, Crowley JR, Epelman S, Weihl CC, Diwan A, Fan D, Mittendorfer B, Stitziel NO, Schilling JD, Lodhi IJ, Razani B. Zhang X, et al. Among authors: epelman s. Nat Metab. 2020 Sep;2(9):991. doi: 10.1038/s42255-020-00291-6. Nat Metab. 2020. PMID: 32908252
134 results